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- W2608413680 abstract "We present a synthetic approach to a highly pathogen-selective detection and delivery platform based on the interaction of an antibody nanovalve with a tetrasaccharide from the O-antigen of the lipopolysaccharide (LPS) of Francisella tularensis bacteria, a Tier 1 Select Agent of bioterrorism. Different design considerations are explored, and proof-of-concept for highly pathogen-specific cargo release from mesoporous silica nanoparticles is demonstrated by comparisons of the release of a signal transducer and model drug by LPS from F. tularensis vs Pseudomonas aeruginosa and by F. tularensis live bacteria vs the closely related bacterium Francisella novocida. In addition to the specific response to a biowarfare agent, treatment of infectious diseases in general could benefit tremendously from a delivery platform that releases its antibiotic payload only at the site of infection and only in the presence of the target pathogen, thereby minimizing off-target toxicities." @default.
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- W2608413680 date "2017-05-05" @default.
- W2608413680 modified "2023-10-17" @default.
- W2608413680 title "A Pathogen-Specific Cargo Delivery Platform Based on Mesoporous Silica Nanoparticles" @default.
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- W2608413680 doi "https://doi.org/10.1021/jacs.7b01278" @default.
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