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• W2608421253 abstract "Sleep disturbances afflict more than half of the 10% of US children with atopic dermatitis(AD). This study aims to characterize limb movements and sleep architecture in a cohort of patients who underwent PSG and were coincidentally noted to have a diagnosis of AD. Retrospective chart review over the past 10 years was performed in patients aged 1.5-17y who underwent polysomnography at Lurie Children’s Hospital and were seen for AD within one year of PSG. Severity of AD was categorized as moderate (regular use of ≤class 5 steroids) v. mild. Patients with AHI >5 were excluded. Descriptive statistics were used to characterize the AD patients. AD patients with Limb Movements Index(LMI) > 15/hr were compared to a control group of age matched patients without AD but with LMI > 15/hr. This was done to determine whether arousal patterns related to limb movements was different in AD patients. Overall, 34 patients met criteria for inclusion, aged 6.4y±3.2 (µ±SD), 50%male, 4 moderate disease. The sleep architecture and efficiency were normal in this cohort of AD with mild disease. However, wake after sleep onset (46min±37.8), limb movement index (32.8 ± 13.9) and arousal indices (14.4 ± 7.5) were elevated compared to Scholle published normative values. Comparing AD with LMI>15/hr (n=7) to children without AD and LMI>15/hr (n=8), total LMI was similar in AD patient compared to controls (24.1 ± 5.8 v. 30.1 ± 9.4, p=0.06), although LMI during wake was greater in AD (118.1/hr±27.1 v 66.4 ± 26.7, p<0.05). LMI with arousals was almost half in AD v. controls (8.6/hr±3.0 v. 16.0/hr±6.8, p<0.01). In the 8 patients with AD who had ferritin measured, only 2 had values slightly below reference range, 20ng/mL in both. Limb movements in AD occur in higher frequency during wake bouts than in non-AD patients with high nocturnal limb movements. Interestingly, despite our control group having a similar LMI, cortical arousals related to limb movements were much higher in non-AD patients. Further work is ongoing to determine the mechanism by which AD patients are having less cortical arousals related to limb movements as compared to non-AD patients with similar LMI." @default.
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• W2608421253 date "2017-04-28" @default.
• W2608421253 modified "2023-09-28" @default.
• W2608421253 title "0946 RETROSPECTIVE CHART REVIEW DEFINING CHARACTERISTICS OF LIMB MOVEMENTS ON POLYSOMNOGRAPHY IN CHILDREN WITH ATOPIC DERMATITIS" @default.
• W2608421253 doi "https://doi.org/10.1093/sleepj/zsx050.945" @default.
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