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- W2608486592 abstract "A 41-year-old woman presented with dizziness, syncope and pallor. A full blood count showed a leucocyte count of 9·8 × 109/l, haemoglobin concentration of 64 g/l and platelet count of 51·4 × 109/l. Biochemical investigations showed impaired renal function (creatinine 117 μmol/l, baseline 62 μmol/l) and marked elevation of immunoglobulin (Ig)G (77·5 g/l). Bone marrow showed increased plasma cells (top) with 15% CD138-positive cells (bottom left). However, there was no kappa/lambda chain restriction and most of the plasma cells were IgG4 positive (bottom right). Serum immunofixation showed increased IgG, kappa and lambda with no monoclonal gammopathy. Abdomen ultrasonography showed no hepatosplenomegaly or other abnormalities. A diagnosis of IgG4-related disease (IgG4-RD) was made and the patient received prednisolone therapy for a year with improvement of anaemia. Bone marrow involvement has rarely been reported in IgG4-RD, which typically manifests with lymphadenopathy, pancreatitis and cholangitis. A recently reported case, confirmed on lymph node biopsy, had progressive anaemia, submandibular gland swelling and bone marrow involvement (Ichiki et al, 2016). In our patient, the disease features related solely to bone marrow involvement and resembled those of multiple myeloma." @default.
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- W2608486592 date "2017-04-25" @default.
- W2608486592 modified "2023-10-04" @default.
- W2608486592 title "IgG4-related disease with bone marrow involvement mimicking multiple myeloma" @default.
- W2608486592 cites W2515000869 @default.
- W2608486592 doi "https://doi.org/10.1111/bjh.14651" @default.
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