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- W2608487687 abstract "Significance Chronic pancreatitis is a progressive inflammatory disease that inflicts hundreds of thousands of people annually in the United State alone, and it has no effective treatment. In the present paper we develop a mathematical model of the progression of the disease and use the model to evaluate the effect of two potential drugs, anti-TNF- <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML overflow=scroll> <mml:mi>α</mml:mi> </mml:math> and anti-IL-6. The model is represented by a system of partial differential equations with carefully estimated parameters. The simulation of the model shows that both drugs can reduce significantly the progressive fibrosis of the pancreas. The model has the potential to generate an interesting clinically testable hypothesis." @default.
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- W2608487687 date "2017-04-24" @default.
- W2608487687 modified "2023-10-16" @default.
- W2608487687 title "Mathematical model of chronic pancreatitis" @default.
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- W2608487687 doi "https://doi.org/10.1073/pnas.1620264114" @default.
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