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• W2608500049 abstract "Abstract MicroRNA‐145 (miR‐145), as a tumor‐suppressive miRNA, has been demonstrated down‐regulated in colorectal cancer (CRC) cells, and could inhibit CRC cells growth. However, the molecular pathway in which miR‐145 modulates CRC malignant transformation has not been fully revealed. Here, we reported an intense correlation between the expressions of PAK4 and miR‐145 in human CRC cell lines. Transwell assay verified overexpression of miR‐145, as well as knockdown of PAK4, significantly suppressed cell migration and invasion ability. The impaired migration and invasion ability of SW1116 cells was affected through the down‐regulation of phosphorylation level of LIMK1 and cofilin in a PAK4‐dependent manner. Collectively, we have demonstrated that miR‐145 suppressed CRC migration and invasion through PAK4 pathway, which provides an attractive microRNA‐based therapeutic target for CRC." @default.
• W2608500049 created "2017-05-05" @default.
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• W2608500049 date "2017-04-24" @default.
• W2608500049 modified "2023-10-14" @default.
• W2608500049 title "MiR‐145 inhibits human colorectal cancer cell migration and invasion via PAK4‐dependent pathway" @default.
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• W2608500049 doi "https://doi.org/10.1002/cam4.1029" @default.
• W2608500049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5463071" @default.
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