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• W2608594552 abstract "Abstract We discuss several well-established, as well as emerging, roles of transient receptor potential (TRP) channels now considered to be important in the pathophysiology of the respiratory system. We introduce the relevance of TRPs to sensing the physical and chemical environment and airborne irritants. A summary of the current knowledge of TRP channel function in different airway cell types, including sensory neurons, airway smooth muscle, and epithelial cells, is presented. We focus on several well-studied in this respect TRP subtypes, describing their expression patterns in cell types relevant to respiratory disorders, and their responsiveness to noxious stimuli. Within this broad context, we finally discuss the rationale for pharmacological targeting of various TRPs (beyond TRPA1) in respiratory disease. We have assembled the accumulating evidence according to channel subtypes, rather than specific pathology, to highlight the multiple roles of individual TRP members in different respiratory disorders." @default.
• W2608594552 created "2017-05-05" @default.
• W2608594552 creator A5025596285 @default.
• W2608594552 creator A5039619617 @default.
• W2608594552 creator A5088456234 @default.
• W2608594552 date "2015-01-01" @default.
• W2608594552 modified "2023-09-24" @default.
• W2608594552 title "TRPs in Respiratory Disorders" @default.
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