FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2608674250> ?p ?o ?g. }

• W2608674250 endingPage "205" @default.
• W2608674250 startingPage "203" @default.
• W2608674250 abstract "Solar ultraviolet (UV) radiation has many adverse effects on the skin. UV can cause inflammation, immunosuppression, skin cancer and premature skin aging (photoaging) [ 1 Armstrong B.K. Kricker A. The epidemiology of UV induced skin cancer. J. Photochem. Photobiol. B. 2001; 63: 8-18 Crossref PubMed Scopus (1342) Google Scholar , 2 Kligman L.H. The ultraviolet-irradiated hairless mouse: a model for photoaging. J. Am. Acad. Dermatol. 1989; 21: 623-631 Abstract Full Text PDF PubMed Scopus (96) Google Scholar ]. Clinically, photoaged skin is recognizable by fine and coarse wrinkles, dyspigmentation and telangiectasia [ [3] Chung J.H. Photoaging in Asians. Photodermatol. Photoimmunol. Photomed. 2003; 19: 109-121 Crossref PubMed Scopus (215) Google Scholar ]. Biologically, one of the important hallmarks of photoaged skin is disrupted expression of collagen. Disruption of collagen by UV results from decreased procollagen synthesis and/or increased collagen degradation [ [4] Rittie L. Fisher G.J. UV-light-induced signal cascades and skin aging. Ageing Res. Rev. 2002; 1: 705-720 Crossref PubMed Scopus (737) Google Scholar ]. Type I collagen is the most abundant collagen in the skin. UV inhibits new type I collagen synthesis through stimulating transcription factor AP-1 and impairing transforming growth factor (TGF-β) signaling pathways [ [4] Rittie L. Fisher G.J. UV-light-induced signal cascades and skin aging. Ageing Res. Rev. 2002; 1: 705-720 Crossref PubMed Scopus (737) Google Scholar ]. Matrix metalloproteinases (MMPs) are key mediators responsible for degradation of extracellular matrix (ECM) proteins including collagen. MMPs could be classified as collagenases, stromelysins, and gelatinases, according to their substrate specificities [ [5] Quan T. Qin Z. Xia W. Shao Y. Voorhees J.J. Fisher G.J. Matrix-degrading metalloproteinases in photoaging. J. Investig. Dermatol. Symp. Proc. 2009; 14: 20-24 Abstract Full Text Full Text PDF PubMed Scopus (497) Google Scholar ]. UV induces activation of mitogen-activated protein kinases (MAPKs). Once MAPKs are activated, they increase expression of AP-1 which in turn results in up-regulation of MMPs [ [4] Rittie L. Fisher G.J. UV-light-induced signal cascades and skin aging. Ageing Res. Rev. 2002; 1: 705-720 Crossref PubMed Scopus (737) Google Scholar ]. UV can induce at least three distinct MMPs in human skin in vivo which are MMP-1 (interstitial collagenase), MMP-3 (stromelysin-1), and MMP-9 (92 kDa gelatinase). The combined actions of MMP-1, MMP-3, and MMP-9 could degrade most of the ECM proteins in dermis [ [5] Quan T. Qin Z. Xia W. Shao Y. Voorhees J.J. Fisher G.J. Matrix-degrading metalloproteinases in photoaging. J. Investig. Dermatol. Symp. Proc. 2009; 14: 20-24 Abstract Full Text Full Text PDF PubMed Scopus (497) Google Scholar ]." @default.
• W2608674250 created "2017-05-05" @default.
• W2608674250 creator A5006805600 @default.
• W2608674250 creator A5012380108 @default.
• W2608674250 creator A5014087113 @default.
• W2608674250 creator A5032707769 @default.
• W2608674250 creator A5052963355 @default.
• W2608674250 creator A5056846121 @default.
• W2608674250 creator A5085529522 @default.
• W2608674250 creator A5088264894 @default.
• W2608674250 date "2017-08-01" @default.
• W2608674250 modified "2023-09-25" @default.
• W2608674250 title "Toll-like receptor 3 mediates UVB-induced MMP-13 and MMP-3 expressions in mice" @default.
• W2608674250 cites W1728722352 @default.
• W2608674250 cites W1852423686 @default.
• W2608674250 cites W1966724428 @default.
• W2608674250 cites W2004160265 @default.
• W2608674250 cites W2024837178 @default.
• W2608674250 cites W2070131223 @default.
• W2608674250 cites W2086882580 @default.
• W2608674250 cites W2089194126 @default.
• W2608674250 cites W2154957444 @default.
• W2608674250 doi "https://doi.org/10.1016/j.jdermsci.2017.04.012" @default.
• W2608674250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28495119" @default.
• W2608674250 hasPublicationYear "2017" @default.
• W2608674250 type Work @default.
• W2608674250 sameAs 2608674250 @default.
• W2608674250 citedByCount "1" @default.
• W2608674250 countsByYear W26086742502019 @default.
• W2608674250 crossrefType "journal-article" @default.
• W2608674250 hasAuthorship W2608674250A5006805600 @default.
• W2608674250 hasAuthorship W2608674250A5012380108 @default.
• W2608674250 hasAuthorship W2608674250A5014087113 @default.
• W2608674250 hasAuthorship W2608674250A5032707769 @default.
• W2608674250 hasAuthorship W2608674250A5052963355 @default.
• W2608674250 hasAuthorship W2608674250A5056846121 @default.
• W2608674250 hasAuthorship W2608674250A5085529522 @default.
• W2608674250 hasAuthorship W2608674250A5088264894 @default.
• W2608674250 hasConcept C109523444 @default.
• W2608674250 hasConcept C16005928 @default.
• W2608674250 hasConcept C181199279 @default.
• W2608674250 hasConcept C185592680 @default.
• W2608674250 hasConcept C2776960578 @default.
• W2608674250 hasConcept C2778394429 @default.
• W2608674250 hasConcept C2909910311 @default.
• W2608674250 hasConcept C502942594 @default.
• W2608674250 hasConcept C55493867 @default.
• W2608674250 hasConcept C71924100 @default.
• W2608674250 hasConceptScore W2608674250C109523444 @default.
• W2608674250 hasConceptScore W2608674250C16005928 @default.
• W2608674250 hasConceptScore W2608674250C181199279 @default.
• W2608674250 hasConceptScore W2608674250C185592680 @default.
• W2608674250 hasConceptScore W2608674250C2776960578 @default.
• W2608674250 hasConceptScore W2608674250C2778394429 @default.
• W2608674250 hasConceptScore W2608674250C2909910311 @default.
• W2608674250 hasConceptScore W2608674250C502942594 @default.
• W2608674250 hasConceptScore W2608674250C55493867 @default.
• W2608674250 hasConceptScore W2608674250C71924100 @default.
• W2608674250 hasIssue "2" @default.
• W2608674250 hasLocation W26086742501 @default.
• W2608674250 hasLocation W26086742502 @default.
• W2608674250 hasOpenAccess W2608674250 @default.
• W2608674250 hasPrimaryLocation W26086742501 @default.
• W2608674250 hasRelatedWork W2036354969 @default.
• W2608674250 hasRelatedWork W2047618294 @default.
• W2608674250 hasRelatedWork W2344151935 @default.
• W2608674250 hasRelatedWork W2353423512 @default.
• W2608674250 hasRelatedWork W2809556991 @default.
• W2608674250 hasRelatedWork W3094034316 @default.
• W2608674250 hasRelatedWork W3166758718 @default.
• W2608674250 hasRelatedWork W4285992260 @default.
• W2608674250 hasRelatedWork W4289868972 @default.
• W2608674250 hasRelatedWork W2472752898 @default.
• W2608674250 hasVolume "87" @default.
• W2608674250 isParatext "false" @default.
• W2608674250 isRetracted "false" @default.
• W2608674250 magId "2608674250" @default.
• W2608674250 workType "article" @default.