Matches in SemOpenAlex for { <https://semopenalex.org/work/W2608675160> ?p ?o ?g. }
- W2608675160 endingPage "162" @default.
- W2608675160 startingPage "156" @default.
- W2608675160 abstract "DNA methylation is a biochemical process that modifies gene expression without changing the underlying DNA sequence, and this represents the molecular basis for imprinting and epigenetics. Recent reports have revealed alterations in DNA methylation profiles in the placenta of babies born from assisted reproductive technologies (ART). This supports several previous observations that suggested an increase in the prevalence of imprinting diseases following ART treatment, and also fits our observations regarding the metabolism and requirements of early human embryos. Human embryo culture media (HECM) are currently formulated according to requirements based on the mouse embryo model, and in fact need to pass the Mouse Embryo Assay test in order to be accepted by the relevant authorities, despite the fact that physiological (especially the time necessary to reach genomic activation) and biochemical requirements of mouse and human embryos are quite different. This commentary aims to explain some of the discrepancies, and emphasize why human embryo metabolism tells us that the composition of HECM, as well as the role of the MEA as a unique model, should be re-evaluated." @default.
- W2608675160 created "2017-05-05" @default.
- W2608675160 creator A5018547727 @default.
- W2608675160 creator A5051922259 @default.
- W2608675160 creator A5056362884 @default.
- W2608675160 date "2017-04-25" @default.
- W2608675160 modified "2023-10-04" @default.
- W2608675160 title "Time to re-evaluate ART protocols in the light of advances in knowledge about methylation and epigenetics: an opinion paper" @default.
- W2608675160 cites W1528420768 @default.
- W2608675160 cites W1772146646 @default.
- W2608675160 cites W1969955520 @default.
- W2608675160 cites W1974890378 @default.
- W2608675160 cites W1984071072 @default.
- W2608675160 cites W1990283447 @default.
- W2608675160 cites W1997866877 @default.
- W2608675160 cites W2002413208 @default.
- W2608675160 cites W2002840152 @default.
- W2608675160 cites W2011825869 @default.
- W2608675160 cites W2016618798 @default.
- W2608675160 cites W2023427185 @default.
- W2608675160 cites W2024758751 @default.
- W2608675160 cites W2028783031 @default.
- W2608675160 cites W2034647076 @default.
- W2608675160 cites W2041165812 @default.
- W2608675160 cites W2048637593 @default.
- W2608675160 cites W2050546718 @default.
- W2608675160 cites W2075086500 @default.
- W2608675160 cites W2087626419 @default.
- W2608675160 cites W2097814975 @default.
- W2608675160 cites W2103522511 @default.
- W2608675160 cites W2107202213 @default.
- W2608675160 cites W2110194655 @default.
- W2608675160 cites W2111075937 @default.
- W2608675160 cites W2112484452 @default.
- W2608675160 cites W2118676910 @default.
- W2608675160 cites W2126657029 @default.
- W2608675160 cites W2127869286 @default.
- W2608675160 cites W2132474673 @default.
- W2608675160 cites W2136810152 @default.
- W2608675160 cites W2140325497 @default.
- W2608675160 cites W2148016791 @default.
- W2608675160 cites W2148271572 @default.
- W2608675160 cites W2153523586 @default.
- W2608675160 cites W2157980542 @default.
- W2608675160 cites W2162860583 @default.
- W2608675160 cites W2163592640 @default.
- W2608675160 cites W2165329755 @default.
- W2608675160 cites W2167020978 @default.
- W2608675160 cites W2167887541 @default.
- W2608675160 cites W2170408710 @default.
- W2608675160 cites W2205944324 @default.
- W2608675160 cites W2302504690 @default.
- W2608675160 cites W2343552610 @default.
- W2608675160 cites W2511638023 @default.
- W2608675160 cites W2524587664 @default.
- W2608675160 cites W39426010 @default.
- W2608675160 doi "https://doi.org/10.1080/14647273.2017.1317846" @default.
- W2608675160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28438071" @default.
- W2608675160 hasPublicationYear "2017" @default.
- W2608675160 type Work @default.
- W2608675160 sameAs 2608675160 @default.
- W2608675160 citedByCount "10" @default.
- W2608675160 countsByYear W26086751602018 @default.
- W2608675160 countsByYear W26086751602019 @default.
- W2608675160 countsByYear W26086751602020 @default.
- W2608675160 countsByYear W26086751602021 @default.
- W2608675160 countsByYear W26086751602022 @default.
- W2608675160 countsByYear W26086751602023 @default.
- W2608675160 crossrefType "journal-article" @default.
- W2608675160 hasAuthorship W2608675160A5018547727 @default.
- W2608675160 hasAuthorship W2608675160A5051922259 @default.
- W2608675160 hasAuthorship W2608675160A5056362884 @default.
- W2608675160 hasConcept C104317684 @default.
- W2608675160 hasConcept C150194340 @default.
- W2608675160 hasConcept C190727270 @default.
- W2608675160 hasConcept C196843134 @default.
- W2608675160 hasConcept C201492766 @default.
- W2608675160 hasConcept C33288867 @default.
- W2608675160 hasConcept C41091548 @default.
- W2608675160 hasConcept C54355233 @default.
- W2608675160 hasConcept C60644358 @default.
- W2608675160 hasConcept C70721500 @default.
- W2608675160 hasConcept C86803240 @default.
- W2608675160 hasConcept C94715292 @default.
- W2608675160 hasConceptScore W2608675160C104317684 @default.
- W2608675160 hasConceptScore W2608675160C150194340 @default.
- W2608675160 hasConceptScore W2608675160C190727270 @default.
- W2608675160 hasConceptScore W2608675160C196843134 @default.
- W2608675160 hasConceptScore W2608675160C201492766 @default.
- W2608675160 hasConceptScore W2608675160C33288867 @default.
- W2608675160 hasConceptScore W2608675160C41091548 @default.
- W2608675160 hasConceptScore W2608675160C54355233 @default.
- W2608675160 hasConceptScore W2608675160C60644358 @default.
- W2608675160 hasConceptScore W2608675160C70721500 @default.
- W2608675160 hasConceptScore W2608675160C86803240 @default.
- W2608675160 hasConceptScore W2608675160C94715292 @default.
- W2608675160 hasIssue "3" @default.
- W2608675160 hasLocation W26086751601 @default.