Matches in SemOpenAlex for { <https://semopenalex.org/work/W2608759269> ?p ?o ?g. }
- W2608759269 abstract "Neurons are highly polarized cells with apparent functional and morphological differences between dendrites and axon. A critical determinant for the molecular and functional identity of axonal and dendritic segments is the restricted expression of voltage-gated ion channels (VGCs). Several studies show an uneven distribution of ion channels and their differential regulation within dendrites and axons, which is a prerequisite for an appropriate integration of synaptic inputs and the generation of adequate action potential (AP) firing patterns. This review article will focus on the signaling pathways leading to segmented expression of voltage-gated potassium and sodium ion channels at the neuronal plasma membrane and the regulatory mechanisms ensuring segregated functions. We will also discuss the relevance of proper ion channel targeting for neuronal physiology and how alterations in polarized distribution contribute to neuronal pathology." @default.
- W2608759269 created "2017-05-05" @default.
- W2608759269 creator A5025827079 @default.
- W2608759269 creator A5027812112 @default.
- W2608759269 creator A5064995491 @default.
- W2608759269 creator A5087488820 @default.
- W2608759269 date "2017-04-24" @default.
- W2608759269 modified "2023-10-10" @default.
- W2608759269 title "The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms" @default.
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