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- W2608881027 abstract "Bone morphogenetic protein-2 (BMP2) is a secreted protein that highly expressed in a variety of cancers and contributes to cell proliferation, migration, invasiveness, mobility, metastasis and EMT. However, its clinical significance and biological function in nasopharyngeal carcinoma (NPC) remain unknown up to now. Up-regulation of BMP2 was first observed in NPC cell lines by a genome-wide transcriptome analysis in our previous study. In this study, BMP2 mRNA was detected by qRT-PCR and data showed that it was upregulated in NPC compared with non-cancerous nasopharynx samples. Immunohistochemistry (IHC) analysis in NPC specimens revealed that high BMP2 expression was significantly associated with clinical stage, distant metastasis and shorter survival of NPC patients. Moreover, overexpression of BMP2 in NPC cells promoted cell proliferation, migration, invasiveness and epithelial-mesenchymal transition (EMT). Mechanistically, BMP2 overexpression increase phosphorylated protein level of mTOR, S6K and 4EBP1. Correspondingly, mTORC1 inhibitor rapamycin blocked the effect of BMP2 on NPC cell proliferation and invasion. In conclusion, our results suggest that BMP2 overexpression in NPC enhances proliferation, invasion and EMT of tumor cells through the mTORC1 signaling pathway." @default.
- W2608881027 created "2017-05-05" @default.
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- W2608881027 date "2017-04-28" @default.
- W2608881027 modified "2023-09-25" @default.
- W2608881027 title "BMP2 promotes proliferation and invasion of nasopharyngeal carcinoma cells via mTORC1 pathway" @default.
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- W2608881027 cites W1967903148 @default.
- W2608881027 cites W1969822773 @default.
- W2608881027 cites W1972786003 @default.
- W2608881027 cites W1974484261 @default.
- W2608881027 cites W1984000404 @default.
- W2608881027 cites W1985916142 @default.
- W2608881027 cites W1987484454 @default.
- W2608881027 cites W1991095294 @default.
- W2608881027 cites W2002084575 @default.
- W2608881027 cites W2002637162 @default.
- W2608881027 cites W2017286592 @default.
- W2608881027 cites W2020777546 @default.
- W2608881027 cites W2024847643 @default.
- W2608881027 cites W2027568954 @default.
- W2608881027 cites W2028248192 @default.
- W2608881027 cites W2031889414 @default.
- W2608881027 cites W2032265199 @default.
- W2608881027 cites W2033251175 @default.
- W2608881027 cites W2034048017 @default.
- W2608881027 cites W2038227634 @default.
- W2608881027 cites W2044050970 @default.
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- W2608881027 cites W2056048839 @default.
- W2608881027 cites W2056984915 @default.
- W2608881027 cites W2059297110 @default.
- W2608881027 cites W2059660194 @default.
- W2608881027 cites W2064033691 @default.
- W2608881027 cites W2065063645 @default.
- W2608881027 cites W2065699924 @default.
- W2608881027 cites W2066901290 @default.
- W2608881027 cites W2070346955 @default.
- W2608881027 cites W2070592678 @default.
- W2608881027 cites W2072493854 @default.
- W2608881027 cites W2083552739 @default.
- W2608881027 cites W2084609943 @default.
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- W2608881027 cites W2092344861 @default.
- W2608881027 cites W2093654042 @default.
- W2608881027 cites W2095454991 @default.
- W2608881027 cites W2117111440 @default.
- W2608881027 cites W2127063807 @default.
- W2608881027 cites W2127357183 @default.
- W2608881027 cites W2129898088 @default.
- W2608881027 cites W2131959709 @default.
- W2608881027 cites W2135556091 @default.
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- W2608881027 cites W2148185823 @default.
- W2608881027 cites W2148358116 @default.
- W2608881027 cites W2154568166 @default.
- W2608881027 cites W2164247184 @default.
- W2608881027 cites W2165857410 @default.
- W2608881027 cites W2311984763 @default.
- W2608881027 cites W2339777559 @default.
- W2608881027 cites W2341835262 @default.
- W2608881027 cites W2437694517 @default.
- W2608881027 cites W2524784007 @default.
- W2608881027 cites W2551392994 @default.
- W2608881027 cites W2555012325 @default.
- W2608881027 cites W2580948701 @default.
- W2608881027 cites W326368786 @default.
- W2608881027 cites W4211070369 @default.
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- W2608881027 doi "https://doi.org/10.18632/aging.101230" @default.
- W2608881027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5425130" @default.
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- W2608881027 hasPublicationYear "2017" @default.
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