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• W2608888206 abstract "Aims The microbiome is the term used for the symbiotic microbial colonisation of healthy organs. Studies have found bacterial identifiers within voided urine which is apparently sterile on conventional laboratory culture, and accordingly there may be health and disease implications. Methods The International Consultation on Incontinence Research Society (ICI‐RS) established a literature review and expert consensus discussion focussed on the increasing awareness of the urinary microbiome, and potential research priorities. Results The consensus considered the discrepancy between findings of conventional clinical microbiology methods, which generally rely on culture parameters predisposed towards certain “expected” organisms. Discrepancy between selective culture and RNA sequencing to study species‐specific 16S ribosomal RNA is increasingly clear, and highlights the possibility that protective or harmful bacteria may be overlooked where microbiological methods are selective. There are now strong signals of the existence of a “core” urinary microbiome for the human urinary tract, particularly emerging with ageing. The consensus reviewed the potential relationship between a patient's microbiome and lower urinary tract dysfunction, whether low‐count bacteriuria may be clinically significant and mechanisms which could associate micro‐organisms with lower urinary tract symptoms. Conclusions Key research priorities identified include the need to establish the scope of microbiome across the range of normality and clinical presentations, and gain consensus on testing protocols. Proteomics to study enzymatic and other functions may be necessary, since different bacteria may have overlapping phenotype. Longitudinal studies into risk factors for exposure, cumulative risk, and emergence of disease need to undertaken. Neurourol. Urodynam. 36:850–853, 2017 . © 2017 Wiley Periodicals, Inc." @default.
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• W2608888206 date "2017-04-01" @default.
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• W2608888206 title "The urinary microbiome and its contribution to lower urinary tract symptoms; ICI-RS 2015" @default.
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• W2608888206 doi "https://doi.org/10.1002/nau.23006" @default.
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