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• W2608959905 abstract "A microfluidic assay for monitoring the inhibition of thrombin peptidase activity was developed. The system, which utilised soluble reagents in continuous-flow injection mode, was configured so as to allow inhibitor titrations via gradient formation. This microfluidic continuous-flow injection titration assay (CFITA) enabled the potency of a set of small-molecule serine peptidase inhibitors (SPIs) to be evaluated. The results, compared to standard microtiter plate (MTP) data, indicated that a microfluidic CFITA provided an efficient and effective method for evaluating compound potency. Crucially, whereas for fast-acting compounds the rank order of potency between the CFITA and MTP methods was preserved, for slow-acting compounds the observed CFITA potencies were significantly lower. These results, in conjunction with data from computer simulations, clearly demonstrated that continuous-flow assays, and perhaps microfluidic assays in general, must take into account binding kinetics when used to assess reaction criteria." @default.
• W2608959905 created "2017-05-05" @default.
• W2608959905 creator A5016632658 @default.
• W2608959905 creator A5080940582 @default.
• W2608959905 date "2017-07-01" @default.
• W2608959905 modified "2023-10-13" @default.
• W2608959905 title "Continuous-flow injection microfluidic thrombin assays: The effect of binding kinetics on observed enzyme inhibition" @default.
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• W2608959905 doi "https://doi.org/10.1016/j.ab.2017.04.016" @default.
• W2608959905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28456636" @default.
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