FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2608989818> ?p ?o ?g. }

• W2608989818 endingPage "362.e6" @default.
• W2608989818 startingPage "362.e1" @default.
• W2608989818 abstract "Background Cesarean delivery is a common surgery in the United States, with 1.3 million performed during 2009. 1 Martin J.A. Hamilton B.E. Ventura S.J. Osterman M.J. Wilson E.C. Mathews T. Births: final data for 2010. Natl Vital Stat Rep. 2012; 61: 1-72 Google Scholar Obstetricians must balance the growing concern with opioid abuse, dependence, and side effects with optimal postoperative pain control. Intravenous acetaminophen may represent an additional method to decrease the reliance on opioid medications and improve postoperative pain following cesarean delivery. Objective The objective of the study was to determine whether the administration of intravenous acetaminophen following routine scheduled cesarean delivery would decrease the need for narcotic medications to control postoperative pain. Study Design This was an institutional review board–approved, double-blind, placebo-controlled, randomized trial, registered on clinicaltrials.gov (number 02046382). Women scheduled to undergo cesarean delivery with regional anesthesia at term were recruited. All perioperative and postpartum care was standardized via study order sets. Study patients were given all medications in a standardized manner receiving either acetaminophen 1000 mg intravenously or 100 mL saline (placebo) every 8 hours for 48 hours for a total of 6 doses. The pharmacy prepared intravenous acetaminophen and saline in identical administration bags labeled study drug to ensure blinding. The initial dose of study drug was given within 60 minutes of skin incision. Quantity of breakthrough and scheduled analgesic medications and self-reported pain levels on the Faces Pain Scale (0–10) before and after study drug administration were collected. Patient demographics were extracted from the chart. Power calculation determined that 45 patients per arm were required to detect a 30% reduction in postcesarean narcotic requirement with 80% power and a significance level of P = .05. Results A total of 133 patients were consented for the study. Twenty-nine were excluded and 104 patients completed the study: 57 received intravenous acetaminophen and 47 received placebo. There were no differences in baseline demographic characteristics including patient age, body mass index, gravidity, parity, race, comorbidities, or number of prior cesarean deliveries. There were no differences between groups in estimated blood loss or length of stay. The total amount of oral narcotic medications consumed by patients receiving intravenous acetaminophen was significantly reduced when compared with the placebo group (47 mg vs 65 mg of oxycodone; P = .034). The total amount of ibuprofen used between groups was not different. There was no difference in pain scores between groups before and after study dose administration. There was no significant difference in narcotic side effects (nausea/emesis, respiratory depression, constipation) in either study arm. Conclusion Intravenous acetaminophen in the postoperative period following cesarean delivery resulted in a significant decrease in oral narcotic consumption for pain control. Cesarean delivery is a common surgery in the United States, with 1.3 million performed during 2009. 1 Martin J.A. Hamilton B.E. Ventura S.J. Osterman M.J. Wilson E.C. Mathews T. Births: final data for 2010. Natl Vital Stat Rep. 2012; 61: 1-72 Google Scholar Obstetricians must balance the growing concern with opioid abuse, dependence, and side effects with optimal postoperative pain control. Intravenous acetaminophen may represent an additional method to decrease the reliance on opioid medications and improve postoperative pain following cesarean delivery. The objective of the study was to determine whether the administration of intravenous acetaminophen following routine scheduled cesarean delivery would decrease the need for narcotic medications to control postoperative pain. This was an institutional review board–approved, double-blind, placebo-controlled, randomized trial, registered on clinicaltrials.gov (number 02046382). Women scheduled to undergo cesarean delivery with regional anesthesia at term were recruited. All perioperative and postpartum care was standardized via study order sets. Study patients were given all medications in a standardized manner receiving either acetaminophen 1000 mg intravenously or 100 mL saline (placebo) every 8 hours for 48 hours for a total of 6 doses. The pharmacy prepared intravenous acetaminophen and saline in identical administration bags labeled study drug to ensure blinding. The initial dose of study drug was given within 60 minutes of skin incision. Quantity of breakthrough and scheduled analgesic medications and self-reported pain levels on the Faces Pain Scale (0–10) before and after study drug administration were collected. Patient demographics were extracted from the chart. Power calculation determined that 45 patients per arm were required to detect a 30% reduction in postcesarean narcotic requirement with 80% power and a significance level of P = .05. A total of 133 patients were consented for the study. Twenty-nine were excluded and 104 patients completed the study: 57 received intravenous acetaminophen and 47 received placebo. There were no differences in baseline demographic characteristics including patient age, body mass index, gravidity, parity, race, comorbidities, or number of prior cesarean deliveries. There were no differences between groups in estimated blood loss or length of stay. The total amount of oral narcotic medications consumed by patients receiving intravenous acetaminophen was significantly reduced when compared with the placebo group (47 mg vs 65 mg of oxycodone; P = .034). The total amount of ibuprofen used between groups was not different. There was no difference in pain scores between groups before and after study dose administration. There was no significant difference in narcotic side effects (nausea/emesis, respiratory depression, constipation) in either study arm. Intravenous acetaminophen in the postoperative period following cesarean delivery resulted in a significant decrease in oral narcotic consumption for pain control." @default.
• W2608989818 created "2017-05-05" @default.
• W2608989818 creator A5022363675 @default.
• W2608989818 creator A5041611494 @default.
• W2608989818 creator A5051569911 @default.
• W2608989818 creator A5083806063 @default.
• W2608989818 date "2017-09-01" @default.
• W2608989818 modified "2023-10-18" @default.
• W2608989818 title "Randomized controlled trial of intravenous acetaminophen for postcesarean delivery pain control" @default.
• W2608989818 cites W1008157409 @default.
• W2608989818 cites W1503767200 @default.
• W2608989818 cites W1975963777 @default.
• W2608989818 cites W1983215991 @default.
• W2608989818 cites W2004866670 @default.
• W2608989818 cites W2015743927 @default.
• W2608989818 cites W2022187897 @default.
• W2608989818 cites W2032229493 @default.
• W2608989818 cites W2034157855 @default.
• W2608989818 cites W2058906610 @default.
• W2608989818 cites W2126047189 @default.
• W2608989818 cites W2144043609 @default.
• W2608989818 cites W2300492567 @default.
• W2608989818 cites W2318217468 @default.
• W2608989818 cites W2319317039 @default.
• W2608989818 cites W4233950920 @default.
• W2608989818 doi "https://doi.org/10.1016/j.ajog.2017.04.030" @default.
• W2608989818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28455085" @default.
• W2608989818 hasPublicationYear "2017" @default.
• W2608989818 type Work @default.
• W2608989818 sameAs 2608989818 @default.
• W2608989818 citedByCount "34" @default.
• W2608989818 countsByYear W26089898182018 @default.
• W2608989818 countsByYear W26089898182019 @default.
• W2608989818 countsByYear W26089898182020 @default.
• W2608989818 countsByYear W26089898182021 @default.
• W2608989818 countsByYear W26089898182022 @default.
• W2608989818 countsByYear W26089898182023 @default.
• W2608989818 crossrefType "journal-article" @default.
• W2608989818 hasAuthorship W2608989818A5022363675 @default.
• W2608989818 hasAuthorship W2608989818A5041611494 @default.
• W2608989818 hasAuthorship W2608989818A5051569911 @default.
• W2608989818 hasAuthorship W2608989818A5083806063 @default.
• W2608989818 hasConcept C126322002 @default.
• W2608989818 hasConcept C141071460 @default.
• W2608989818 hasConcept C142724271 @default.
• W2608989818 hasConcept C168563851 @default.
• W2608989818 hasConcept C170493617 @default.
• W2608989818 hasConcept C204787440 @default.
• W2608989818 hasConcept C27081682 @default.
• W2608989818 hasConcept C2771230 @default.
• W2608989818 hasConcept C2777397205 @default.
• W2608989818 hasConcept C2778722691 @default.
• W2608989818 hasConcept C2780820201 @default.
• W2608989818 hasConcept C2781063702 @default.
• W2608989818 hasConcept C31174226 @default.
• W2608989818 hasConcept C42219234 @default.
• W2608989818 hasConcept C71924100 @default.
• W2608989818 hasConceptScore W2608989818C126322002 @default.
• W2608989818 hasConceptScore W2608989818C141071460 @default.
• W2608989818 hasConceptScore W2608989818C142724271 @default.
• W2608989818 hasConceptScore W2608989818C168563851 @default.
• W2608989818 hasConceptScore W2608989818C170493617 @default.
• W2608989818 hasConceptScore W2608989818C204787440 @default.
• W2608989818 hasConceptScore W2608989818C27081682 @default.
• W2608989818 hasConceptScore W2608989818C2771230 @default.
• W2608989818 hasConceptScore W2608989818C2777397205 @default.
• W2608989818 hasConceptScore W2608989818C2778722691 @default.
• W2608989818 hasConceptScore W2608989818C2780820201 @default.
• W2608989818 hasConceptScore W2608989818C2781063702 @default.
• W2608989818 hasConceptScore W2608989818C31174226 @default.
• W2608989818 hasConceptScore W2608989818C42219234 @default.
• W2608989818 hasConceptScore W2608989818C71924100 @default.
• W2608989818 hasIssue "3" @default.
• W2608989818 hasLocation W26089898181 @default.
• W2608989818 hasLocation W26089898182 @default.
• W2608989818 hasOpenAccess W2608989818 @default.
• W2608989818 hasPrimaryLocation W26089898181 @default.
• W2608989818 hasRelatedWork W1983842309 @default.
• W2608989818 hasRelatedWork W2006151192 @default.
• W2608989818 hasRelatedWork W2023452855 @default.
• W2608989818 hasRelatedWork W2035710886 @default.
• W2608989818 hasRelatedWork W2037531766 @default.
• W2608989818 hasRelatedWork W2054310303 @default.
• W2608989818 hasRelatedWork W2289353593 @default.
• W2608989818 hasRelatedWork W2431245822 @default.
• W2608989818 hasRelatedWork W2465676392 @default.
• W2608989818 hasRelatedWork W66115843 @default.
• W2608989818 hasVolume "217" @default.
• W2608989818 isParatext "false" @default.
• W2608989818 isRetracted "false" @default.
• W2608989818 magId "2608989818" @default.
• W2608989818 workType "article" @default.