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- W2609010682 abstract "Eutirucallin is a lectin isolated from the latex of Euphorbia tirucalli, a plant known for its medical properties. The present study explores various characteristics of Eutirucallin including stability, cytotoxicity against tumor cells, antimicrobial and antiparasitic activities. Eutirucallin was stable from 2 to 40 days at 4°C, maintained hemagglutinating activity within a restricted range, and showed optimal activity at pH 7.0-8.0. Eutirucallin presented antiproliferative activity for HeLa, PC3, MDA-MB-231, and MCF-7 tumor cells but was not cytotoxic for non-tumorigenic cells such as macrophages and fibroblasts. Eutirucallin inhibited the Ehrlich ascites carcinoma in vivo and it was also observed that Eutirucallin inhibited 62.5% of Escherichia coli growth. Also, Eutirucallin showed to be effective when tested directly against Toxoplasma gondii infection in vitro. Therefore, this study sheds perspectives for pharmacological applications of Eutirucallin." @default.
- W2609010682 created "2017-05-05" @default.
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- W2609010682 date "2017-04-25" @default.
- W2609010682 modified "2023-10-06" @default.
- W2609010682 title "Eutirucallin: A Lectin with Antitumor and Antimicrobial Properties" @default.
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- W2609010682 doi "https://doi.org/10.3389/fcimb.2017.00136" @default.
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