Matches in SemOpenAlex for { <https://semopenalex.org/work/W2609148711> ?p ?o ?g. }
- W2609148711 endingPage "205" @default.
- W2609148711 startingPage "199" @default.
- W2609148711 abstract "Anti-hepatitis B virus (HBV) activity was evaluated in HepG2 2.2.15 cells by novel Baicalein derivatives. The result showed that compounds 4k and 4h was found to be effective anti-HBV agent. Further, the effect of compounds 4k and 4h showed dose-dependent inhibition of HBV-DNA as compared to control together with significant inhibition of HbeAG and HbsAG expression in the tested dose. Both compounds showed considerable affinity against the HepG2.2.15 cells. Moreover, the docking study of compound 4k was carried out with HLA molecule showing excellent intermolecular interactions with the receptor via creation of numerous bonds with Ser5, Thr27, Asp29 and Phe8. The compound 4k showed significant effect on the HO-1 expression in HepG2.2.15 cells together with excellent anti-HBV activity in transgenic mouse confirmed by biochemical and histopathological parameters. Compound 4k also showed excellent pharmacokinetic profile in experimental animal and thus, provide a novel class of potent anti-HBV agents." @default.
- W2609148711 created "2017-05-05" @default.
- W2609148711 creator A5005215310 @default.
- W2609148711 creator A5005801799 @default.
- W2609148711 creator A5015339437 @default.
- W2609148711 creator A5030007770 @default.
- W2609148711 creator A5031530137 @default.
- W2609148711 creator A5034902358 @default.
- W2609148711 creator A5050550539 @default.
- W2609148711 creator A5058513000 @default.
- W2609148711 creator A5066552139 @default.
- W2609148711 creator A5087802995 @default.
- W2609148711 creator A5090608407 @default.
- W2609148711 date "2017-07-01" @default.
- W2609148711 modified "2023-09-27" @default.
- W2609148711 title "Discovery and mechanism of action of Novel Baicalein modified derivatives as potent antihepatitis agent" @default.
- W2609148711 cites W175109609 @default.
- W2609148711 cites W1944130481 @default.
- W2609148711 cites W1965220796 @default.
- W2609148711 cites W1966851944 @default.
- W2609148711 cites W1973080494 @default.
- W2609148711 cites W1974283678 @default.
- W2609148711 cites W1988875702 @default.
- W2609148711 cites W1989213595 @default.
- W2609148711 cites W1995168175 @default.
- W2609148711 cites W1995853598 @default.
- W2609148711 cites W2003104968 @default.
- W2609148711 cites W2016288426 @default.
- W2609148711 cites W2029126794 @default.
- W2609148711 cites W2029527941 @default.
- W2609148711 cites W2050488495 @default.
- W2609148711 cites W2087564721 @default.
- W2609148711 cites W2087954267 @default.
- W2609148711 cites W2101041237 @default.
- W2609148711 cites W2123859926 @default.
- W2609148711 cites W2147946898 @default.
- W2609148711 cites W2158534713 @default.
- W2609148711 cites W2159392789 @default.
- W2609148711 cites W2160643911 @default.
- W2609148711 cites W2163274841 @default.
- W2609148711 cites W2167830402 @default.
- W2609148711 cites W4301466201 @default.
- W2609148711 doi "https://doi.org/10.1016/j.virol.2017.04.002" @default.
- W2609148711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28453983" @default.
- W2609148711 hasPublicationYear "2017" @default.
- W2609148711 type Work @default.
- W2609148711 sameAs 2609148711 @default.
- W2609148711 citedByCount "5" @default.
- W2609148711 countsByYear W26091487112018 @default.
- W2609148711 countsByYear W26091487112020 @default.
- W2609148711 countsByYear W26091487112021 @default.
- W2609148711 countsByYear W26091487112022 @default.
- W2609148711 crossrefType "journal-article" @default.
- W2609148711 hasAuthorship W2609148711A5005215310 @default.
- W2609148711 hasAuthorship W2609148711A5005801799 @default.
- W2609148711 hasAuthorship W2609148711A5015339437 @default.
- W2609148711 hasAuthorship W2609148711A5030007770 @default.
- W2609148711 hasAuthorship W2609148711A5031530137 @default.
- W2609148711 hasAuthorship W2609148711A5034902358 @default.
- W2609148711 hasAuthorship W2609148711A5050550539 @default.
- W2609148711 hasAuthorship W2609148711A5058513000 @default.
- W2609148711 hasAuthorship W2609148711A5066552139 @default.
- W2609148711 hasAuthorship W2609148711A5087802995 @default.
- W2609148711 hasAuthorship W2609148711A5090608407 @default.
- W2609148711 hasBestOaLocation W26091487111 @default.
- W2609148711 hasConcept C12554922 @default.
- W2609148711 hasConcept C159047783 @default.
- W2609148711 hasConcept C159110408 @default.
- W2609148711 hasConcept C185592680 @default.
- W2609148711 hasConcept C202751555 @default.
- W2609148711 hasConcept C21951064 @default.
- W2609148711 hasConcept C2522874641 @default.
- W2609148711 hasConcept C2775940106 @default.
- W2609148711 hasConcept C2776120743 @default.
- W2609148711 hasConcept C2777410769 @default.
- W2609148711 hasConcept C2780593183 @default.
- W2609148711 hasConcept C2781466915 @default.
- W2609148711 hasConcept C41685203 @default.
- W2609148711 hasConcept C55493867 @default.
- W2609148711 hasConcept C71240020 @default.
- W2609148711 hasConcept C71924100 @default.
- W2609148711 hasConcept C86803240 @default.
- W2609148711 hasConcept C98274493 @default.
- W2609148711 hasConceptScore W2609148711C12554922 @default.
- W2609148711 hasConceptScore W2609148711C159047783 @default.
- W2609148711 hasConceptScore W2609148711C159110408 @default.
- W2609148711 hasConceptScore W2609148711C185592680 @default.
- W2609148711 hasConceptScore W2609148711C202751555 @default.
- W2609148711 hasConceptScore W2609148711C21951064 @default.
- W2609148711 hasConceptScore W2609148711C2522874641 @default.
- W2609148711 hasConceptScore W2609148711C2775940106 @default.
- W2609148711 hasConceptScore W2609148711C2776120743 @default.
- W2609148711 hasConceptScore W2609148711C2777410769 @default.
- W2609148711 hasConceptScore W2609148711C2780593183 @default.
- W2609148711 hasConceptScore W2609148711C2781466915 @default.
- W2609148711 hasConceptScore W2609148711C41685203 @default.
- W2609148711 hasConceptScore W2609148711C55493867 @default.
- W2609148711 hasConceptScore W2609148711C71240020 @default.