FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2609187905> ?p ?o ?g. }

• W2609187905 abstract "ABSTRACT The capsid domain (CA) of the retroviral Gag protein is a primary determinant of Gag oligomerization, which is a critical step for immature Gag lattice formation and virus particle budding. Although the human immunodeficiency virus type 1 (HIV-1) CA carboxy-terminal domain (CTD) is essential for CA-CA interactions, the CA CTD has been suggested to be largely dispensable for human T-cell leukemia virus type 1 (HTLV-1) particle biogenesis. To more clearly define the roles of the HTLV-1 CA amino-terminal domain (NTD) and CA CTD in particle biogenesis, we generated and analyzed a panel of Gag proteins with chimeric HIV-1/HTLV-1 CA domains. Subcellular distribution and protein expression levels indicated that Gag proteins with a chimeric HIV-1 CA NTD/HTLV-1 CA CTD did not result in Gag oligomerization regardless of the parent Gag background. Furthermore, chimeric Gag proteins with the HTLV-1 CA NTD produced particles phenotypically similar to HTLV-1 immature particles, highlighting the importance of the HTLV-1 CA NTD in HTLV-1 immature particle morphology. Taken together, these observations support the conclusion that the HTLV-1 CA NTD can functionally replace the HIV-1 CA CTD, but the HIV-1 CA NTD cannot replace the HTLV-1 CA CTD, indicating that the HTLV-1 CA subdomains provide distinct contributions to Gag-Gag oligomerization, particle morphology, and biogenesis. Furthermore, we have shown for the first time that HIV-1 and HTLV-1 Gag domains outside the CA (e.g., matrix and nucleocapsid) impact Gag oligomerization as well as immature particle size and morphology. IMPORTANCE A key aspect in virus replication is virus particle assembly, which is a poorly understood process for most viruses. For retroviruses, the Gag structural protein is the primary driver of virus particle biogenesis, and the CA CTD is the primary determinant of Gag-Gag interactions for HIV-1. In this study, the HTLV-1 capsid amino-terminal domain was found to provide distinct contributions to Gag-Gag oligomerization, particle morphology, and biogenesis. This study provides information that will aid efforts for discovery of therapeutic targets for intervention." @default.
• W2609187905 created "2017-05-05" @default.
• W2609187905 creator A5040548950 @default.
• W2609187905 creator A5045325939 @default.
• W2609187905 creator A5057734727 @default.
• W2609187905 creator A5068050265 @default.
• W2609187905 creator A5070237638 @default.
• W2609187905 creator A5083799319 @default.
• W2609187905 date "2017-07-15" @default.
• W2609187905 modified "2023-10-18" @default.
• W2609187905 title "Disparate Contributions of Human Retrovirus Capsid Subdomains to Gag-Gag Oligomerization, Virus Morphology, and Particle Biogenesis" @default.
• W2609187905 cites W1547343486 @default.
• W2609187905 cites W1562103219 @default.
• W2609187905 cites W1579191879 @default.
• W2609187905 cites W1823429634 @default.
• W2609187905 cites W1834333351 @default.
• W2609187905 cites W1892628669 @default.
• W2609187905 cites W1966655306 @default.
• W2609187905 cites W1968718594 @default.
• W2609187905 cites W1969836275 @default.
• W2609187905 cites W1972717662 @default.
• W2609187905 cites W1973705658 @default.
• W2609187905 cites W1976366669 @default.
• W2609187905 cites W1982944348 @default.
• W2609187905 cites W1991879937 @default.
• W2609187905 cites W1993184461 @default.
• W2609187905 cites W1993573856 @default.
• W2609187905 cites W1994475804 @default.
• W2609187905 cites W2006370953 @default.
• W2609187905 cites W2007703482 @default.
• W2609187905 cites W2013652077 @default.
• W2609187905 cites W2015090760 @default.
• W2609187905 cites W2021064626 @default.
• W2609187905 cites W2023916724 @default.
• W2609187905 cites W2027300565 @default.
• W2609187905 cites W2031235040 @default.
• W2609187905 cites W2042649563 @default.
• W2609187905 cites W2045028231 @default.
• W2609187905 cites W2046182783 @default.
• W2609187905 cites W2047816956 @default.
• W2609187905 cites W2053762237 @default.
• W2609187905 cites W2054218295 @default.
• W2609187905 cites W2054452833 @default.
• W2609187905 cites W2057712924 @default.
• W2609187905 cites W2061411549 @default.
• W2609187905 cites W2063385224 @default.
• W2609187905 cites W2064166253 @default.
• W2609187905 cites W2068488050 @default.
• W2609187905 cites W2076467539 @default.
• W2609187905 cites W2087978946 @default.
• W2609187905 cites W2094653829 @default.
• W2609187905 cites W2094788348 @default.
• W2609187905 cites W2096621401 @default.
• W2609187905 cites W2105093369 @default.
• W2609187905 cites W2107758050 @default.
• W2609187905 cites W2114461447 @default.
• W2609187905 cites W2115221527 @default.
• W2609187905 cites W2117109344 @default.
• W2609187905 cites W2147556444 @default.
• W2609187905 cites W2152534499 @default.
• W2609187905 cites W2152539875 @default.
• W2609187905 cites W2153388351 @default.
• W2609187905 cites W2156696460 @default.
• W2609187905 cites W2167157589 @default.
• W2609187905 cites W2167680425 @default.
• W2609187905 cites W2172285292 @default.
• W2609187905 cites W2208465122 @default.
• W2609187905 cites W2216096160 @default.
• W2609187905 cites W2270865938 @default.
• W2609187905 cites W2348038103 @default.
• W2609187905 cites W2472495991 @default.
• W2609187905 cites W2519276118 @default.
• W2609187905 cites W4249774679 @default.
• W2609187905 doi "https://doi.org/10.1128/jvi.00298-17" @default.
• W2609187905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5487576" @default.
• W2609187905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28446667" @default.
• W2609187905 hasPublicationYear "2017" @default.
• W2609187905 type Work @default.
• W2609187905 sameAs 2609187905 @default.
• W2609187905 citedByCount "14" @default.
• W2609187905 countsByYear W26091879052018 @default.
• W2609187905 countsByYear W26091879052019 @default.
• W2609187905 countsByYear W26091879052021 @default.
• W2609187905 countsByYear W26091879052022 @default.
• W2609187905 countsByYear W26091879052023 @default.
• W2609187905 crossrefType "journal-article" @default.
• W2609187905 hasAuthorship W2609187905A5040548950 @default.
• W2609187905 hasAuthorship W2609187905A5045325939 @default.
• W2609187905 hasAuthorship W2609187905A5057734727 @default.
• W2609187905 hasAuthorship W2609187905A5068050265 @default.
• W2609187905 hasAuthorship W2609187905A5070237638 @default.
• W2609187905 hasAuthorship W2609187905A5083799319 @default.
• W2609187905 hasBestOaLocation W26091879051 @default.
• W2609187905 hasConcept C104317684 @default.
• W2609187905 hasConcept C123894998 @default.
• W2609187905 hasConcept C131934819 @default.
• W2609187905 hasConcept C153911025 @default.
• W2609187905 hasConcept C159047783 @default.
• W2609187905 hasConcept C202878990 @default.
• W2609187905 hasConcept C2522874641 @default.

• next