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- W2609207777 abstract "Human clinical studies conducted with LCI699 established aldosterone synthase (CYP11B2) inhibition as a promising novel mechanism to lower arterial blood pressure. However, LCI699’s low CYP11B1/CYP11B2 selectivity resulted in blunting of adrenocorticotropic hormone-stimulated cortisol secretion. This property of LCI699 prompted its development in Cushing’s disease, but limited more extensive clinical studies in hypertensive populations, and provided an impetus for the search for cortisol-sparing CYP11B2 inhibitors. This paper summarizes the discovery, pharmacokinetics, and pharmacodynamics data in pre-clinical species and human subjects of the selective CYP11B2 inhibitor LFF269 (8)." @default.
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- W2609207777 date "2015-01-01" @default.
- W2609207777 modified "2023-09-24" @default.
- W2609207777 title "Discovery of LFF269, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects" @default.
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