FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2609322495> ?p ?o ?g. }

• W2609322495 endingPage "353" @default.
• W2609322495 startingPage "353" @default.
• W2609322495 abstract "Several human diseases have been associated with mitochondrial voltage-dependent anion channel-1 (VDAC1) due to its role in calcium ion transportation and apoptosis. Recent studies suggest that VDAC1 may interact with endothelium-dependent nitric oxide synthase (eNOS). Decreased VDAC1 expression may limit the physical interaction between VDAC1 and eNOS and thus impair nitric oxide production, leading to cardiovascular diseases, including pulmonary arterial hypertension (PAH). In this report, we conducted meta-analysis of genome-wide expression data to identify VDAC1 influenced genes implicated in PAH pathobiology. First, we identified the genes differentially expressed between wild-type and Vdac1 knockout mouse embryonic fibroblasts in hypoxic conditions. These genes were deemed to be influenced by VDAC1 deficiency. Gene ontology analysis indicates that the VDAC1 influenced genes are significantly associated with PAH pathobiology. Second, a molecular signature derived from the VDAC1 influenced genes was developed. We suggest that, VDAC1 has a protective role in PAH and the gene expression signature of VDAC1 influenced genes can be used to i) predict severity of pulmonary hypertension secondary to pulmonary diseases, ii) differentiate idiopathic pulmonary artery hypertension (IPAH) patients from controls, and iii) differentiate IPAH from connective tissue disease associated PAH." @default.
• W2609322495 created "2017-05-05" @default.
• W2609322495 creator A5007927256 @default.
• W2609322495 creator A5009794773 @default.
• W2609322495 creator A5024165645 @default.
• W2609322495 creator A5047780314 @default.
• W2609322495 creator A5054192049 @default.
• W2609322495 creator A5055436613 @default.
• W2609322495 creator A5061590846 @default.
• W2609322495 creator A5081941278 @default.
• W2609322495 creator A5087731777 @default.
• W2609322495 date "2017-01-01" @default.
• W2609322495 modified "2023-09-23" @default.
• W2609322495 title "Expression profile of mitochondrial voltage-dependent anion channel-1 (VDAC1) influenced genes is associated with pulmonary hypertension" @default.
• W2609322495 cites W1075217855 @default.
• W2609322495 cites W1561180410 @default.
• W2609322495 cites W1991852898 @default.
• W2609322495 cites W1996985763 @default.
• W2609322495 cites W1997632305 @default.
• W2609322495 cites W1999356873 @default.
• W2609322495 cites W2020277250 @default.
• W2609322495 cites W2020419820 @default.
• W2609322495 cites W2020541351 @default.
• W2609322495 cites W2022397091 @default.
• W2609322495 cites W2029768468 @default.
• W2609322495 cites W2037393370 @default.
• W2609322495 cites W2040296083 @default.
• W2609322495 cites W2051607469 @default.
• W2609322495 cites W2065915608 @default.
• W2609322495 cites W2072144231 @default.
• W2609322495 cites W2072752280 @default.
• W2609322495 cites W2076396596 @default.
• W2609322495 cites W2096487938 @default.
• W2609322495 cites W2097347505 @default.
• W2609322495 cites W2098148891 @default.
• W2609322495 cites W2098571225 @default.
• W2609322495 cites W2101960743 @default.
• W2609322495 cites W2103017472 @default.
• W2609322495 cites W2111013440 @default.
• W2609322495 cites W2115339119 @default.
• W2609322495 cites W2120675651 @default.
• W2609322495 cites W2123213425 @default.
• W2609322495 cites W2131676053 @default.
• W2609322495 cites W2138550913 @default.
• W2609322495 cites W2140258011 @default.
• W2609322495 cites W2146190354 @default.
• W2609322495 cites W2147937572 @default.
• W2609322495 cites W2150838171 @default.
• W2609322495 cites W2157795344 @default.
• W2609322495 cites W2166101849 @default.
• W2609322495 cites W2501807035 @default.
• W2609322495 cites W4294107304 @default.
• W2609322495 doi "https://doi.org/10.4196/kjpp.2017.21.3.353" @default.
• W2609322495 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5409118" @default.
• W2609322495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28461778" @default.
• W2609322495 hasPublicationYear "2017" @default.
• W2609322495 type Work @default.
• W2609322495 sameAs 2609322495 @default.
• W2609322495 citedByCount "3" @default.
• W2609322495 countsByYear W26093224952020 @default.
• W2609322495 countsByYear W26093224952021 @default.
• W2609322495 countsByYear W26093224952023 @default.
• W2609322495 crossrefType "journal-article" @default.
• W2609322495 hasAuthorship W2609322495A5007927256 @default.
• W2609322495 hasAuthorship W2609322495A5009794773 @default.
• W2609322495 hasAuthorship W2609322495A5024165645 @default.
• W2609322495 hasAuthorship W2609322495A5047780314 @default.
• W2609322495 hasAuthorship W2609322495A5054192049 @default.
• W2609322495 hasAuthorship W2609322495A5055436613 @default.
• W2609322495 hasAuthorship W2609322495A5061590846 @default.
• W2609322495 hasAuthorship W2609322495A5081941278 @default.
• W2609322495 hasAuthorship W2609322495A5087731777 @default.
• W2609322495 hasBestOaLocation W26093224952 @default.
• W2609322495 hasConcept C104317684 @default.
• W2609322495 hasConcept C126322002 @default.
• W2609322495 hasConcept C146587185 @default.
• W2609322495 hasConcept C2777622882 @default.
• W2609322495 hasConcept C2778326061 @default.
• W2609322495 hasConcept C2779058106 @default.
• W2609322495 hasConcept C2780930700 @default.
• W2609322495 hasConcept C519581460 @default.
• W2609322495 hasConcept C54355233 @default.
• W2609322495 hasConcept C547475151 @default.
• W2609322495 hasConcept C71924100 @default.
• W2609322495 hasConcept C86803240 @default.
• W2609322495 hasConceptScore W2609322495C104317684 @default.
• W2609322495 hasConceptScore W2609322495C126322002 @default.
• W2609322495 hasConceptScore W2609322495C146587185 @default.
• W2609322495 hasConceptScore W2609322495C2777622882 @default.
• W2609322495 hasConceptScore W2609322495C2778326061 @default.
• W2609322495 hasConceptScore W2609322495C2779058106 @default.
• W2609322495 hasConceptScore W2609322495C2780930700 @default.
• W2609322495 hasConceptScore W2609322495C519581460 @default.
• W2609322495 hasConceptScore W2609322495C54355233 @default.
• W2609322495 hasConceptScore W2609322495C547475151 @default.
• W2609322495 hasConceptScore W2609322495C71924100 @default.
• W2609322495 hasConceptScore W2609322495C86803240 @default.
• W2609322495 hasIssue "3" @default.

• next