Matches in SemOpenAlex for { <https://semopenalex.org/work/W2609490042> ?p ?o ?g. }
- W2609490042 endingPage "565" @default.
- W2609490042 startingPage "557" @default.
- W2609490042 abstract "Context: Hospital workers are at risk for genotoxic damage following occupationally exposure to xenobiotics. Pathologists are exposed to chemicals during their use in health care environments, particularly throughout inhalation of airborne agents, absorption through skin or contact with the patient’s body fluids.Objective: We evaluated the level of genomic damage in a sample of 61 hospital pathologists (occupationally exposed to antineoplastic drugs and sterilizing agents) and 60 control subjects.Materials and methods: Lymphocytes were analyzed by SCEs and CAs assays and genotyped for GSTT1, GSTM1, CYP1A1 Ile/Val, XPD (A751C) and XPC (A939C) gene polymorphisms.Results: Pathologists showed significantly higher frequencies of SCEs and CAs with respect to control subjects. GSTT1 null genotype was found to be associated with higher SCEs and CAs frequencies, whereas XPD 751 CC and XPC 939 CC genotypes only with a higher level of SCEs.Discussion and conclusions: The SCEs and CAs results are consistent with other published data, placing hospital workers as a category at risk for genotoxic damage caused by chronic exposure to xenobiotics. The higher levels of cytogenetic damage observed among GSTT1 null, XPD 751 and XPC 939 CC homozygote subjects confirm the importance of the genetic polymorphisms analysis associated to genotoxicological studies." @default.
- W2609490042 created "2017-05-05" @default.
- W2609490042 creator A5002484445 @default.
- W2609490042 creator A5018682883 @default.
- W2609490042 creator A5027083675 @default.
- W2609490042 creator A5044005943 @default.
- W2609490042 creator A5048115759 @default.
- W2609490042 creator A5072251764 @default.
- W2609490042 creator A5079578509 @default.
- W2609490042 creator A5091709203 @default.
- W2609490042 date "2017-05-04" @default.
- W2609490042 modified "2023-09-26" @default.
- W2609490042 title "Association of <i>GSTT1</i> null, <i>XPD</i> 751 CC and <i>XPC</i> 939 CC genotypes with increased levels of genomic damage among hospital pathologists" @default.
- W2609490042 cites W1507190685 @default.
- W2609490042 cites W1750764013 @default.
- W2609490042 cites W1966711127 @default.
- W2609490042 cites W1967730770 @default.
- W2609490042 cites W1972967534 @default.
- W2609490042 cites W1977439202 @default.
- W2609490042 cites W1978847799 @default.
- W2609490042 cites W1987791430 @default.
- W2609490042 cites W1989180829 @default.
- W2609490042 cites W1994945319 @default.
- W2609490042 cites W1996593212 @default.
- W2609490042 cites W1996628366 @default.
- W2609490042 cites W2006222399 @default.
- W2609490042 cites W2008115513 @default.
- W2609490042 cites W2012236235 @default.
- W2609490042 cites W2026621373 @default.
- W2609490042 cites W2026776398 @default.
- W2609490042 cites W2031600422 @default.
- W2609490042 cites W2034832355 @default.
- W2609490042 cites W2040289024 @default.
- W2609490042 cites W2040436901 @default.
- W2609490042 cites W2049394451 @default.
- W2609490042 cites W2051918551 @default.
- W2609490042 cites W2052178019 @default.
- W2609490042 cites W2052339469 @default.
- W2609490042 cites W2058300961 @default.
- W2609490042 cites W2060902588 @default.
- W2609490042 cites W2069347831 @default.
- W2609490042 cites W2070821144 @default.
- W2609490042 cites W2076732453 @default.
- W2609490042 cites W2083806987 @default.
- W2609490042 cites W2086187998 @default.
- W2609490042 cites W2095872281 @default.
- W2609490042 cites W2105430503 @default.
- W2609490042 cites W2108192168 @default.
- W2609490042 cites W2109951137 @default.
- W2609490042 cites W2111598528 @default.
- W2609490042 cites W2112159784 @default.
- W2609490042 cites W2114180794 @default.
- W2609490042 cites W2115344173 @default.
- W2609490042 cites W2122085176 @default.
- W2609490042 cites W2123750457 @default.
- W2609490042 cites W2124401677 @default.
- W2609490042 cites W2134767616 @default.
- W2609490042 cites W2137930112 @default.
- W2609490042 cites W2149774379 @default.
- W2609490042 cites W2158045853 @default.
- W2609490042 cites W2165967711 @default.
- W2609490042 cites W2168916587 @default.
- W2609490042 cites W2171413948 @default.
- W2609490042 cites W2200613921 @default.
- W2609490042 cites W2357686274 @default.
- W2609490042 cites W4232157403 @default.
- W2609490042 doi "https://doi.org/10.1080/1354750x.2017.1322147" @default.
- W2609490042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28434254" @default.
- W2609490042 hasPublicationYear "2017" @default.
- W2609490042 type Work @default.
- W2609490042 sameAs 2609490042 @default.
- W2609490042 citedByCount "7" @default.
- W2609490042 countsByYear W26094900422020 @default.
- W2609490042 countsByYear W26094900422021 @default.
- W2609490042 countsByYear W26094900422022 @default.
- W2609490042 countsByYear W26094900422023 @default.
- W2609490042 crossrefType "journal-article" @default.
- W2609490042 hasAuthorship W2609490042A5002484445 @default.
- W2609490042 hasAuthorship W2609490042A5018682883 @default.
- W2609490042 hasAuthorship W2609490042A5027083675 @default.
- W2609490042 hasAuthorship W2609490042A5044005943 @default.
- W2609490042 hasAuthorship W2609490042A5048115759 @default.
- W2609490042 hasAuthorship W2609490042A5072251764 @default.
- W2609490042 hasAuthorship W2609490042A5079578509 @default.
- W2609490042 hasAuthorship W2609490042A5091709203 @default.
- W2609490042 hasConcept C104317684 @default.
- W2609490042 hasConcept C115448650 @default.
- W2609490042 hasConcept C126322002 @default.
- W2609490042 hasConcept C135763542 @default.
- W2609490042 hasConcept C146304588 @default.
- W2609490042 hasConcept C151730666 @default.
- W2609490042 hasConcept C181199279 @default.
- W2609490042 hasConcept C2776954882 @default.
- W2609490042 hasConcept C2779343474 @default.
- W2609490042 hasConcept C2779990520 @default.
- W2609490042 hasConcept C2909231917 @default.
- W2609490042 hasConcept C2987845665 @default.
- W2609490042 hasConcept C3017497123 @default.