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- W2609493536 abstract "Hypothalamic proline-rich peptide-1 (PRP-1), a neurosecretory cytokine appeared to be involved in the multiple mechanisms of cardioprotection. Dose-dependent effects of PRP-1 (4 and 8 µg) were studied in an open-chest model of myocardial ischemia-reperfusion injury (IRI). Adult mail Sprague Dawley rats underwent 40-minute left anterior descending coronary artery occlusion, under isoflurane anesthesia followed by 2 and/or 24 h of reperfusion. Groups treated with PRP-1 were compared to control and it has been revealed that the efficient dose of PRP-1 can restore in a time-dependent manner the contractile activity of the myocardium and suppress the both inflammation and necrosis via amelioration of oxidative stress in the cardiac tissues there through contributing to the in vivo reduction of myocardial infarct volume and an improvement the cardiac hemodynamics and coronary circulation. New studies are needed to ascertain a beneficial effect of PRP-1 in humans and its future clinic use for the myocardial IRI treatment." @default.
- W2609493536 created "2017-05-05" @default.
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- W2609493536 date "2017-03-04" @default.
- W2609493536 modified "2023-09-28" @default.
- W2609493536 title "HYPOTHALAMIC PROLINE-RICH PEPTIDE-1 PROTECTS AGAINST MYOCARDIAL ISCHEMIA-REPERFUSION INJURY" @default.
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- W2609493536 doi "https://doi.org/10.17628/ecb.2017.6.49-53" @default.
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