FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2609638415> ?p ?o ?g. }

• W2609638415 abstract "Vitamin D deficiency (low plasma 25-hydroxyvitamin D [25D] concentration) is often reported in tuberculosis. Adjunctive vitamin D has been tested for its potential to improve treatment outcomes, but has proven largely ineffective. To better understand vitamin D in tuberculosis, we investigated determinants of 25D and its immunologically active form, 1,25-dihydroxyvitamin D (1,25D), their inter-relationship in tuberculosis, longitudinal changes and association with outcome. In a prospective observational study of adults with smear-positive pulmonary tuberculosis in Sabah, Malaysia, we measured serial 25D, 1,25D, vitamin D-binding protein (VDBP), albumin, calcium, parathyroid hormone, chest x-ray, week 8 sputum smear/culture and end-of-treatment outcome. Healthy control subjects were enrolled for comparison. 1,25D was elevated in 172 adults with tuberculosis (mean 229.0 pmol/L, 95% confidence interval: 215.4 - 242.6) compared with 95 controls (153.9, 138.4-169.4, p < 0.001), directly proportional to radiological severity (p < 0.001), and fell rapidly within one week of treatment commencement. Tuberculosis patients with higher baseline 1,25D achieved significantly higher percentage weight gain over time, including when controlling for baseline weight, however persistently elevated 1,25D was associated with worse residual x-ray changes and lower end-of-treatment BMI. 1,25D was inversely associated with PTH (p < 0.001), consistent with the extra-renal origin of the 1,25D. 25D did not differ between tuberculosis patients (mean 63.9 nmol/L, 95% CI: 60.6 - 67.3) and controls (61.3, 57.2- 65.3, p = 0.24), and was unassociated with outcomes. Among tuberculosis patients in multivariable analyses, sex, age and VDBP were associated with 25D, and age and albumin with 1,25D. 1,25-dihydroxyvitamin was not significantly asscociated with 25D. Vitamin D deficiency <25 nmol/L was uncommon, occurring in only five TB patients; 1,25D was elevated in three of them. In an equatorial setting, high extra-renal production of 1,25D was seen in tuberculosis, including in individuals with 25D in the deficient range; however, severe 25D deficiency was uncommon. Baseline elevation of 1,25D, a marker of macrophage activation, was associated with better weight gain but persistent elevation of 1,25D was associated with worse radiological and BMI outcomes. 1,25D warrants testing in larger datasets including TB patients less responsive to treatment, such as multi-drug resistant TB, to test its utility as a marker of tuberculosis severity and treatment response." @default.
• W2609638415 created "2017-05-05" @default.
• W2609638415 creator A5001227530 @default.
• W2609638415 creator A5032095213 @default.
• W2609638415 creator A5038904531 @default.
• W2609638415 creator A5045549244 @default.
• W2609638415 creator A5049596141 @default.
• W2609638415 creator A5068755589 @default.
• W2609638415 creator A5070653684 @default.
• W2609638415 creator A5071403069 @default.
• W2609638415 creator A5083301936 @default.
• W2609638415 creator A5089350667 @default.
• W2609638415 date "2017-04-27" @default.
• W2609638415 modified "2023-10-16" @default.
• W2609638415 title "Vitamin D and activated vitamin D in tuberculosis in equatorial Malaysia: a prospective clinical study" @default.
• W2609638415 cites W108787254 @default.
• W2609638415 cites W1967303080 @default.
• W2609638415 cites W1977197986 @default.
• W2609638415 cites W1994698540 @default.
• W2609638415 cites W2001079134 @default.
• W2609638415 cites W2001654461 @default.
• W2609638415 cites W2011007785 @default.
• W2609638415 cites W2021501597 @default.
• W2609638415 cites W2030338624 @default.
• W2609638415 cites W2035986671 @default.
• W2609638415 cites W2039860912 @default.
• W2609638415 cites W2046106090 @default.
• W2609638415 cites W2048122246 @default.
• W2609638415 cites W2050658609 @default.
• W2609638415 cites W2064376185 @default.
• W2609638415 cites W2065737191 @default.
• W2609638415 cites W2075794139 @default.
• W2609638415 cites W2077089413 @default.
• W2609638415 cites W2085839858 @default.
• W2609638415 cites W2103024679 @default.
• W2609638415 cites W2105702489 @default.
• W2609638415 cites W2121656778 @default.
• W2609638415 cites W2121961071 @default.
• W2609638415 cites W2124580054 @default.
• W2609638415 cites W2136190705 @default.
• W2609638415 cites W2146523219 @default.
• W2609638415 cites W2149592353 @default.
• W2609638415 cites W2151983305 @default.
• W2609638415 cites W2157133006 @default.
• W2609638415 cites W2160589687 @default.
• W2609638415 cites W2164719130 @default.
• W2609638415 cites W2168801650 @default.
• W2609638415 cites W2169198054 @default.
• W2609638415 cites W2289824612 @default.
• W2609638415 cites W2407555036 @default.
• W2609638415 cites W2419178435 @default.
• W2609638415 cites W962612974 @default.
• W2609638415 doi "https://doi.org/10.1186/s12879-017-2314-z" @default.
• W2609638415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5408363" @default.
• W2609638415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28449659" @default.
• W2609638415 hasPublicationYear "2017" @default.
• W2609638415 type Work @default.
• W2609638415 sameAs 2609638415 @default.
• W2609638415 citedByCount "11" @default.
• W2609638415 countsByYear W26096384152018 @default.
• W2609638415 countsByYear W26096384152019 @default.
• W2609638415 countsByYear W26096384152020 @default.
• W2609638415 countsByYear W26096384152021 @default.
• W2609638415 countsByYear W26096384152022 @default.
• W2609638415 crossrefType "journal-article" @default.
• W2609638415 hasAuthorship W2609638415A5001227530 @default.
• W2609638415 hasAuthorship W2609638415A5032095213 @default.
• W2609638415 hasAuthorship W2609638415A5038904531 @default.
• W2609638415 hasAuthorship W2609638415A5045549244 @default.
• W2609638415 hasAuthorship W2609638415A5049596141 @default.
• W2609638415 hasAuthorship W2609638415A5068755589 @default.
• W2609638415 hasAuthorship W2609638415A5070653684 @default.
• W2609638415 hasAuthorship W2609638415A5071403069 @default.
• W2609638415 hasAuthorship W2609638415A5083301936 @default.
• W2609638415 hasAuthorship W2609638415A5089350667 @default.
• W2609638415 hasBestOaLocation W26096384151 @default.
• W2609638415 hasConcept C124490489 @default.
• W2609638415 hasConcept C126322002 @default.
• W2609638415 hasConcept C142724271 @default.
• W2609638415 hasConcept C188816634 @default.
• W2609638415 hasConcept C2776301714 @default.
• W2609638415 hasConcept C2779740938 @default.
• W2609638415 hasConcept C2781069245 @default.
• W2609638415 hasConcept C2781208988 @default.
• W2609638415 hasConcept C44249647 @default.
• W2609638415 hasConcept C519063684 @default.
• W2609638415 hasConcept C71924100 @default.
• W2609638415 hasConcept C90924648 @default.
• W2609638415 hasConceptScore W2609638415C124490489 @default.
• W2609638415 hasConceptScore W2609638415C126322002 @default.
• W2609638415 hasConceptScore W2609638415C142724271 @default.
• W2609638415 hasConceptScore W2609638415C188816634 @default.
• W2609638415 hasConceptScore W2609638415C2776301714 @default.
• W2609638415 hasConceptScore W2609638415C2779740938 @default.
• W2609638415 hasConceptScore W2609638415C2781069245 @default.
• W2609638415 hasConceptScore W2609638415C2781208988 @default.
• W2609638415 hasConceptScore W2609638415C44249647 @default.
• W2609638415 hasConceptScore W2609638415C519063684 @default.
• W2609638415 hasConceptScore W2609638415C71924100 @default.
• W2609638415 hasConceptScore W2609638415C90924648 @default.

• next