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- W2609870363 abstract "In stable renal transplant recipients with hyperparathyroidism, previous studies have indicated that vitamin D agonist treatment might have anti-proteinuric effects. Animal studies indicate possible anti-fibrotic and anti-inflammatory effects. Early introduction of paricalcitol in de novo renal transplant recipients might reduce proteinuria and prevent progressive allograft fibrosis. We performed a single-center, prospective, randomized, open-label trial investigating effects of paricalcitol 2 μg/day added to standard care. Participants were included 8 weeks after engraftment and followed for 44 weeks. Primary end point was change in spot urine albumin/creatinine ratio. Exploratory microarray analyses of kidney biopsies at study end investigated potential effects on gene expression. Secondary end points included change in glomerular filtration rate (GFR), pulse wave velocity (PWV), and endothelial function measured by peripheral arterial tonometry as reactive hyperemia index (RHI). Seventy-seven de novo transplanted kidney allograft recipients were included, 37 receiving paricalcitol. Paricalcitol treatment lowered PTH levels (P = 0.01) but did not significantly reduce albuminuria (P = 0.76), change vascular parameters (PWV; P = 0.98, RHI; P = 0.33), or influence GFR (P = 0.57). Allograft gene expression was not influenced. To summarize, in newly transplanted renal allograft recipients, paricalcitol reduced PTH and was well tolerated without negatively affecting kidney function. Paricalcitol did not significantly reduce/prevent albuminuria, improve parameters of vascular health, or influence allograft gene expression." @default.
- W2609870363 created "2017-05-05" @default.
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- W2609870363 date "2017-06-02" @default.
- W2609870363 modified "2023-10-05" @default.
- W2609870363 title "Early introduction of oral paricalcitol in renal transplant recipients. An open-label randomized study" @default.
- W2609870363 cites W1485319130 @default.
- W2609870363 cites W1518393912 @default.
- W2609870363 cites W1531456964 @default.
- W2609870363 cites W1568816258 @default.
- W2609870363 cites W1839006534 @default.
- W2609870363 cites W1928249844 @default.
- W2609870363 cites W1958413320 @default.
- W2609870363 cites W1976997529 @default.
- W2609870363 cites W1977964953 @default.
- W2609870363 cites W1979147243 @default.
- W2609870363 cites W1982207442 @default.
- W2609870363 cites W1983589399 @default.
- W2609870363 cites W1983954041 @default.
- W2609870363 cites W1985729788 @default.
- W2609870363 cites W1985925148 @default.
- W2609870363 cites W1999033168 @default.
- W2609870363 cites W1999841727 @default.
- W2609870363 cites W2008871724 @default.
- W2609870363 cites W2009228116 @default.
- W2609870363 cites W2021137320 @default.
- W2609870363 cites W2021550803 @default.
- W2609870363 cites W2022890761 @default.
- W2609870363 cites W2023637811 @default.
- W2609870363 cites W2025818283 @default.
- W2609870363 cites W2030352514 @default.
- W2609870363 cites W2031580436 @default.
- W2609870363 cites W2039543568 @default.
- W2609870363 cites W2041297883 @default.
- W2609870363 cites W2046060950 @default.
- W2609870363 cites W2050684606 @default.
- W2609870363 cites W2051921347 @default.
- W2609870363 cites W2053854392 @default.
- W2609870363 cites W2064544773 @default.
- W2609870363 cites W2066496748 @default.
- W2609870363 cites W206846325 @default.
- W2609870363 cites W2070073147 @default.
- W2609870363 cites W2075519141 @default.
- W2609870363 cites W2088071922 @default.
- W2609870363 cites W2090758657 @default.
- W2609870363 cites W2091646497 @default.
- W2609870363 cites W2095527531 @default.
- W2609870363 cites W2109068562 @default.
- W2609870363 cites W2114676504 @default.
- W2609870363 cites W2116079133 @default.
- W2609870363 cites W2121587014 @default.
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- W2609870363 cites W2128193591 @default.
- W2609870363 cites W2128707697 @default.
- W2609870363 cites W2132644547 @default.
- W2609870363 cites W2135910107 @default.
- W2609870363 cites W2139999609 @default.
- W2609870363 cites W2141530260 @default.
- W2609870363 cites W2149500157 @default.
- W2609870363 cites W2150731298 @default.
- W2609870363 cites W2154818624 @default.
- W2609870363 cites W2160619232 @default.
- W2609870363 cites W2162129240 @default.
- W2609870363 cites W2165098078 @default.
- W2609870363 cites W2167507562 @default.
- W2609870363 cites W2210116591 @default.
- W2609870363 cites W2256980043 @default.
- W2609870363 cites W2259516816 @default.
- W2609870363 cites W2304341280 @default.
- W2609870363 cites W2329728034 @default.
- W2609870363 cites W2407353553 @default.
- W2609870363 cites W2575598946 @default.
- W2609870363 cites W4378965300 @default.
- W2609870363 cites W1970587623 @default.
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- W2609870363 doi "https://doi.org/10.1111/tri.12973" @default.
- W2609870363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28436117" @default.
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