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- W260994261 abstract "Inhibitors of ghrelin O-acyltransferase (GOAT) have untapped potential as therapeutics targeting obesity and diabetes. We report the first examples of GOAT inhibitors incorporating a triazole linkage as a biostable isosteric replacement for the ester bond in ghrelin and amide bonds in previously reported GOAT inhibitors. These triazole-containing inhibitors exhibit sub-micromolar inhibition of the human isoform of GOAT (hGOAT), and provide a foundation for rapid future chemical diversification and optimization of hGOAT inhibitors." @default.
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- W260994261 date "2015-07-01" @default.
- W260994261 modified "2023-09-23" @default.
- W260994261 title "A new class of ghrelin O-acyltransferase inhibitors incorporating triazole-linked lipid mimetic groups" @default.
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- W260994261 doi "https://doi.org/10.1016/j.bmcl.2015.05.009" @default.
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