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• W2609977986 startingPage "439" @default.
• W2609977986 abstract "Cells and organisms have evolved numerous mechanisms to cope with and to adapt to unexpected challenges and harsh conditions. Proteins are essential to perform the vast majority of cellular and organismal functions. To maintain a healthy proteome, cells rely on a network of factors and pathways collectively known as protein quality control (PQC) systems, which not only ensure that newly synthesized proteins reach a functional conformation but also are essential for surveillance, prevention, and rescue of protein defects. The main players of PQC systems are chaperones and protein degradation systems: the ubiquitin-proteasome system and autophagy. Here we provide an integrated overview of the diverse PQC systems in eukaryotic cells in health and diseases, with an emphasis on the key regulatory aspects and their cross talks. We also highlight how PQC regulation may be exploited for potential therapeutic benefit." @default.
• W2609977986 created "2017-05-05" @default.
• W2609977986 creator A5060495190 @default.
• W2609977986 creator A5068455515 @default.
• W2609977986 creator A5079454374 @default.
• W2609977986 date "2017-10-06" @default.
• W2609977986 modified "2023-09-29" @default.
• W2609977986 title "Coping with Protein Quality Control Failure" @default.
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