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- W2609979907 abstract "The burden of cardiovascular disease in bipolar disorder (BD) exceeds what can be explained by traditional cardiovascular risk factors (CVRFs), lifestyle, and/or medications. Moreover, neurocognitive deficits are a core feature of BD, and are also related to CVRFs. We examined retinal vascular photography, a proxy for cerebral microvasculature, in relation to CVRFs, peripheral microvascular function, and neurocognition among BD adolescents. Subjects were 30 adolescents with BD and 32 healthy controls (HC). Retinal photography was conducted using a Topcon TRC 50 DX, Type IA camera, following pupil dilation. Retinal arteriolar and venular caliber was measured, from which the arterio-venular ratio (AVR) was computed. All measures were conducted masked to participant diagnosis. Peripheral arterial tonometry measured endothelial function. Neurocognition was assessed using the Cambridge Neuropsychological Tests Automated Battery. AVR was not significantly different between groups (Cohen’s d=0.18, p=0.103). Higher diastolic blood pressure (BP) was associated with lower (worse) AVR in BD (r=−0.441, p=0.015) but not HC (r=−0.192, p=0.293). Similarly, in the BD group only, higher (better) endothelial function was associated with higher AVR (r=0.375, p=0.041). Hierarchical regression models confirmed that, independent of covariates, retinal vascular caliber was significantly associated with diastolic BP and endothelial function in BD. Within the BD group, mood scores were significantly negatively correlated with AVR (β=−0.451, p=0.044). This study’s limitations include a small sample size, a cross-sectional study design, and a heterogeneous sample. Retinal photography may offer unique insights regarding the cardiovascular and neurocognitive burden of BD. Larger longitudinal studies are warranted." @default.
- W2609979907 created "2017-05-05" @default.
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- W2609979907 date "2017-08-01" @default.
- W2609979907 modified "2023-10-16" @default.
- W2609979907 title "Retinal photography: A window into the cardiovascular-brain link in adolescent bipolar disorder" @default.
- W2609979907 cites W1485265893 @default.
- W2609979907 cites W1486300716 @default.
- W2609979907 cites W1507228780 @default.
- W2609979907 cites W1512847190 @default.
- W2609979907 cites W1578986529 @default.
- W2609979907 cites W1600134865 @default.
- W2609979907 cites W1833931272 @default.
- W2609979907 cites W1870853477 @default.
- W2609979907 cites W1907881098 @default.
- W2609979907 cites W1963650892 @default.
- W2609979907 cites W1964377208 @default.
- W2609979907 cites W1965146231 @default.
- W2609979907 cites W1970796985 @default.
- W2609979907 cites W1973080177 @default.
- W2609979907 cites W1974634532 @default.
- W2609979907 cites W1974803357 @default.
- W2609979907 cites W1977214804 @default.
- W2609979907 cites W1978659236 @default.
- W2609979907 cites W1978881364 @default.
- W2609979907 cites W1982874754 @default.
- W2609979907 cites W1983302342 @default.
- W2609979907 cites W1985976318 @default.
- W2609979907 cites W1992240906 @default.
- W2609979907 cites W1993771532 @default.
- W2609979907 cites W1995639937 @default.
- W2609979907 cites W1995904975 @default.
- W2609979907 cites W1996888969 @default.
- W2609979907 cites W1996947415 @default.
- W2609979907 cites W1997263321 @default.
- W2609979907 cites W1997363702 @default.
- W2609979907 cites W2000114818 @default.
- W2609979907 cites W2000784646 @default.
- W2609979907 cites W2001885074 @default.
- W2609979907 cites W2004217515 @default.
- W2609979907 cites W2005061709 @default.
- W2609979907 cites W2009328439 @default.
- W2609979907 cites W2016667558 @default.
- W2609979907 cites W2017214595 @default.
- W2609979907 cites W2017255926 @default.
- W2609979907 cites W2017475376 @default.
- W2609979907 cites W2018149578 @default.
- W2609979907 cites W2023543003 @default.
- W2609979907 cites W2024600467 @default.
- W2609979907 cites W2027432853 @default.
- W2609979907 cites W2027988022 @default.
- W2609979907 cites W2030458803 @default.
- W2609979907 cites W2034530918 @default.
- W2609979907 cites W2034888646 @default.
- W2609979907 cites W2037417771 @default.
- W2609979907 cites W2038922047 @default.
- W2609979907 cites W2039519120 @default.
- W2609979907 cites W2040799860 @default.
- W2609979907 cites W2041026406 @default.
- W2609979907 cites W2041580348 @default.
- W2609979907 cites W2042547858 @default.
- W2609979907 cites W2045779254 @default.
- W2609979907 cites W2048168735 @default.
- W2609979907 cites W2055628680 @default.
- W2609979907 cites W2056437482 @default.
- W2609979907 cites W2056939901 @default.
- W2609979907 cites W2058052047 @default.
- W2609979907 cites W2060761527 @default.
- W2609979907 cites W2061450110 @default.
- W2609979907 cites W2068540352 @default.
- W2609979907 cites W2072684660 @default.
- W2609979907 cites W2073729281 @default.
- W2609979907 cites W2077066095 @default.
- W2609979907 cites W2077457073 @default.
- W2609979907 cites W2078270391 @default.
- W2609979907 cites W2079156367 @default.
- W2609979907 cites W2082818483 @default.
- W2609979907 cites W2087599099 @default.
- W2609979907 cites W2090291588 @default.
- W2609979907 cites W2090496521 @default.
- W2609979907 cites W2090742652 @default.
- W2609979907 cites W2091830069 @default.
- W2609979907 cites W2097005219 @default.
- W2609979907 cites W2097812147 @default.
- W2609979907 cites W2097929804 @default.
- W2609979907 cites W2098800320 @default.
- W2609979907 cites W2100990163 @default.
- W2609979907 cites W2102570761 @default.
- W2609979907 cites W2103879771 @default.
- W2609979907 cites W2104801393 @default.
- W2609979907 cites W2105790910 @default.