Matches in SemOpenAlex for { <https://semopenalex.org/work/W2610006150> ?p ?o ?g. }
- W2610006150 abstract "Objective: Arm motor recovery after stroke is primarily attributed to the primary motor cortex (M1) plasticity. While the M1 contralateral to the paretic arm (cM1) is undoubtedly critical for recovery, the role of the ipsilateral M1 (iM1) is still inconclusive. For instance, an abnormally increased activity in the iM1 is reported immediately after stroke and normalizes at the chronic stage in recovered patients. Whether persistent iM1 hyperactivity in chronic stroke reflects a less efficient type of plasticity (so-called maladaptive) is still far from settled. We investigated the functional significance of the iM1 hyperactivity with respect to compensatory behavioral strategies employed by patients suffering from chronic arm paresis.Methods: Functional MRI and trunk kinematics data were collected during paretic arm movements in 11 patients before and after a four-week training specifically designed to improve the motor control of the paretic arm and diminish the behavioral (trunk) compensation comprising of variable practice of a reach-to-grasp task with feedback given as knowledge-of-performance. Eight age-matched healthy controls underwent similar evaluations and training. Magnitude of iM1 (and cM1) activation and anterior trunk displacement were analysed.Results: Before training, patients exhibited significantly stronger iM1 activation, increased trunk motion, and significant positive correlations between these two variables compared to controls. After training, patients significantly decreased iM1 activation and displayed a trend toward decreased trunk use. The correlations between iM1 activation and trunk motion persisted and were different from those in controls.Conclusion: Our preliminary data provide evidence that functional iM1 plasticity is related to behavioral compensation, suggesting a maladaptive role of the iM1 in chronic subcortical stroke. We however recommend caution in interpreting these results until more work is completed." @default.
- W2610006150 created "2017-05-05" @default.
- W2610006150 creator A5016000906 @default.
- W2610006150 creator A5021390403 @default.
- W2610006150 creator A5028332065 @default.
- W2610006150 creator A5062305835 @default.
- W2610006150 creator A5087861832 @default.
- W2610006150 creator A5089480541 @default.
- W2610006150 date "2017-01-01" @default.
- W2610006150 modified "2023-09-24" @default.
- W2610006150 title "Primary Motor Cortex Ipsilateral to the Paretic Arm - A Potential Neural Substrate for Compensatory Trunk Use in Chronic Stroke" @default.
- W2610006150 cites W15228111 @default.
- W2610006150 cites W1546817039 @default.
- W2610006150 cites W1617736026 @default.
- W2610006150 cites W1855371659 @default.
- W2610006150 cites W1967909987 @default.
- W2610006150 cites W1968476075 @default.
- W2610006150 cites W1968917479 @default.
- W2610006150 cites W1971993148 @default.
- W2610006150 cites W1975914151 @default.
- W2610006150 cites W1976345722 @default.
- W2610006150 cites W1978157075 @default.
- W2610006150 cites W1981990510 @default.
- W2610006150 cites W1982815334 @default.
- W2610006150 cites W1983532871 @default.
- W2610006150 cites W1998408021 @default.
- W2610006150 cites W2004941377 @default.
- W2610006150 cites W2006818837 @default.
- W2610006150 cites W2009782019 @default.
- W2610006150 cites W2014303315 @default.
- W2610006150 cites W2018287553 @default.
- W2610006150 cites W2018676635 @default.
- W2610006150 cites W2019273642 @default.
- W2610006150 cites W2029065091 @default.
- W2610006150 cites W2031592758 @default.
- W2610006150 cites W2039539255 @default.
- W2610006150 cites W2040868194 @default.
- W2610006150 cites W2045539431 @default.
- W2610006150 cites W2050399395 @default.
- W2610006150 cites W2051123042 @default.
- W2610006150 cites W2059331478 @default.
- W2610006150 cites W2059477553 @default.
- W2610006150 cites W2081919223 @default.
- W2610006150 cites W2082719369 @default.
- W2610006150 cites W2084437125 @default.
- W2610006150 cites W2085179476 @default.
- W2610006150 cites W2091931051 @default.
- W2610006150 cites W2094308504 @default.
- W2610006150 cites W2098661447 @default.
- W2610006150 cites W2102756180 @default.
- W2610006150 cites W2103771133 @default.
- W2610006150 cites W2104721123 @default.
- W2610006150 cites W2105158640 @default.
- W2610006150 cites W2107687247 @default.
- W2610006150 cites W2109107402 @default.
- W2610006150 cites W2109431728 @default.
- W2610006150 cites W2110693594 @default.
- W2610006150 cites W2112537700 @default.
- W2610006150 cites W2119248403 @default.
- W2610006150 cites W2121146828 @default.
- W2610006150 cites W2121849906 @default.
- W2610006150 cites W2123357819 @default.
- W2610006150 cites W2124118965 @default.
- W2610006150 cites W2126597767 @default.
- W2610006150 cites W2128535047 @default.
- W2610006150 cites W2129241661 @default.
- W2610006150 cites W2132969169 @default.
- W2610006150 cites W2133776785 @default.
- W2610006150 cites W2136022845 @default.
- W2610006150 cites W2141338501 @default.
- W2610006150 cites W2147464541 @default.
- W2610006150 cites W2149006258 @default.
- W2610006150 cites W2152940329 @default.
- W2610006150 cites W2154898926 @default.
- W2610006150 cites W2155262322 @default.
- W2610006150 cites W2157303434 @default.
- W2610006150 cites W2157795035 @default.
- W2610006150 cites W2158450617 @default.
- W2610006150 cites W2158935809 @default.
- W2610006150 cites W2160523181 @default.
- W2610006150 cites W2163507898 @default.
- W2610006150 cites W2164481855 @default.
- W2610006150 cites W2167289365 @default.
- W2610006150 cites W2171801858 @default.
- W2610006150 cites W3023251708 @default.
- W2610006150 cites W320445500 @default.
- W2610006150 cites W345035824 @default.
- W2610006150 cites W765865495 @default.
- W2610006150 doi "https://doi.org/10.4172/2329-9096.1000400" @default.
- W2610006150 hasPublicationYear "2017" @default.
- W2610006150 type Work @default.
- W2610006150 sameAs 2610006150 @default.
- W2610006150 citedByCount "0" @default.
- W2610006150 crossrefType "journal-article" @default.
- W2610006150 hasAuthorship W2610006150A5016000906 @default.
- W2610006150 hasAuthorship W2610006150A5021390403 @default.
- W2610006150 hasAuthorship W2610006150A5028332065 @default.
- W2610006150 hasAuthorship W2610006150A5062305835 @default.
- W2610006150 hasAuthorship W2610006150A5087861832 @default.
- W2610006150 hasAuthorship W2610006150A5089480541 @default.