Matches in SemOpenAlex for { <https://semopenalex.org/work/W2610021577> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2610021577 abstract "AimsPridopidine is an oral drug in clinical development for treatment of patients with Huntington's disease. This study examined the interactions of pridopidine with in vitro cytochrome P450 activity and characterized the effects of pridopidine on CYP2D6 activity in healthy volunteers using metoprolol as a probe substrate. The effect of food on pridopidine exposure was assessed.MethodsThe ability of pridopidine to inhibit and/or induce in vitro activity of drug metabolizing enzymes was examined in human liver microsomes and fresh hepatocytes. CYP2D6 inhibition potency and reversibility was assessed using dextromethorphan. For the clinical assessment, 22 healthy subjects were given metoprolol 100 mg alone and concomitantly with steady-state pridopidine 45 mg twice daily. Food effect on a single 90 mg dose of pridopidine was evaluated in a crossover manner. Safety assessments and pharmacokinetic sampling occurred throughout the study.ResultsPridopidine was found to be a metabolism dependent inhibitor of CYP2D6, the main enzyme catalysing its own metabolism. Flavin-containing monooxygenase heat inactivation of liver microsomes did not affect pridopidine metabolism-dependent inhibition of CYP2D6 and its inhibition of CYP2D6 was not reversible with addition of FeCN3. Exposure to metoprolol was markedly increased when coadministered with pridopidine; the ratio of the geometric means (90% confidence interval) for maximum observed plasma concentration, and area under the plasma concentration–time curve from time 0 to the time of the last quantifiable concentration and extrapolated to infinity were 3.5 (2.9, 4.22), 6.64 (5.27, 8.38) and 6.55 (5.18, 8.28), respectively. Systemic exposure to pridopidine was unaffected by food conditions.ConclusionsAs pridopidine is a metabolism-dependent inhibitor of CYP2D6, systemic levels of drugs metabolized by CYP2D6 may increase with chronic coadministration of pridopidine. Pridopidine can be administered without regard to food." @default.
- W2610021577 created "2017-05-05" @default.
- W2610021577 creator A5010835408 @default.
- W2610021577 creator A5019378119 @default.
- W2610021577 creator A5045784005 @default.
- W2610021577 creator A5050995972 @default.
- W2610021577 creator A5076108650 @default.
- W2610021577 creator A5077349491 @default.
- W2610021577 date "2017-06-21" @default.
- W2610021577 modified "2023-10-03" @default.
- W2610021577 title "Metoprolol-pridopidine drug-drug interaction and food effect assessments of pridopidine, a new drug for treatment of Huntington's disease" @default.
- W2610021577 cites W1515218878 @default.
- W2610021577 cites W1970732501 @default.
- W2610021577 cites W2003135058 @default.
- W2610021577 cites W2010427019 @default.
- W2610021577 cites W2018505851 @default.
- W2610021577 cites W2034606094 @default.
- W2610021577 cites W2034615747 @default.
- W2610021577 cites W2058543411 @default.
- W2610021577 cites W2063803972 @default.
- W2610021577 cites W2080542847 @default.
- W2610021577 cites W2106289426 @default.
- W2610021577 cites W2119678057 @default.
- W2610021577 cites W2136176655 @default.
- W2610021577 cites W2147963337 @default.
- W2610021577 cites W2152964734 @default.
- W2610021577 cites W2154990516 @default.
- W2610021577 cites W2167093496 @default.
- W2610021577 cites W2167353335 @default.
- W2610021577 cites W2193975711 @default.
- W2610021577 cites W2194756172 @default.
- W2610021577 cites W2196064518 @default.
- W2610021577 cites W2196303538 @default.
- W2610021577 cites W2740215628 @default.
- W2610021577 cites W4232534952 @default.
- W2610021577 doi "https://doi.org/10.1111/bcp.13317" @default.
- W2610021577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5595947" @default.
- W2610021577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28449367" @default.
- W2610021577 hasPublicationYear "2017" @default.
- W2610021577 type Work @default.
- W2610021577 sameAs 2610021577 @default.
- W2610021577 citedByCount "0" @default.
- W2610021577 crossrefType "journal-article" @default.
- W2610021577 hasAuthorship W2610021577A5010835408 @default.
- W2610021577 hasAuthorship W2610021577A5019378119 @default.
- W2610021577 hasAuthorship W2610021577A5045784005 @default.
- W2610021577 hasAuthorship W2610021577A5050995972 @default.
- W2610021577 hasAuthorship W2610021577A5076108650 @default.
- W2610021577 hasAuthorship W2610021577A5077349491 @default.
- W2610021577 hasBestOaLocation W26100215771 @default.
- W2610021577 hasConcept C112705442 @default.
- W2610021577 hasConcept C126322002 @default.
- W2610021577 hasConcept C185592680 @default.
- W2610021577 hasConcept C2780035454 @default.
- W2610021577 hasConcept C2781245242 @default.
- W2610021577 hasConcept C2781280847 @default.
- W2610021577 hasConcept C33664856 @default.
- W2610021577 hasConcept C526171541 @default.
- W2610021577 hasConcept C62231903 @default.
- W2610021577 hasConcept C71924100 @default.
- W2610021577 hasConcept C98274493 @default.
- W2610021577 hasConceptScore W2610021577C112705442 @default.
- W2610021577 hasConceptScore W2610021577C126322002 @default.
- W2610021577 hasConceptScore W2610021577C185592680 @default.
- W2610021577 hasConceptScore W2610021577C2780035454 @default.
- W2610021577 hasConceptScore W2610021577C2781245242 @default.
- W2610021577 hasConceptScore W2610021577C2781280847 @default.
- W2610021577 hasConceptScore W2610021577C33664856 @default.
- W2610021577 hasConceptScore W2610021577C526171541 @default.
- W2610021577 hasConceptScore W2610021577C62231903 @default.
- W2610021577 hasConceptScore W2610021577C71924100 @default.
- W2610021577 hasConceptScore W2610021577C98274493 @default.
- W2610021577 hasFunder F4320308970 @default.
- W2610021577 hasLocation W26100215771 @default.
- W2610021577 hasLocation W26100215772 @default.
- W2610021577 hasOpenAccess W2610021577 @default.
- W2610021577 hasPrimaryLocation W26100215771 @default.
- W2610021577 isParatext "false" @default.
- W2610021577 isRetracted "false" @default.
- W2610021577 magId "2610021577" @default.
- W2610021577 workType "article" @default.