Matches in SemOpenAlex for { <https://semopenalex.org/work/W2610028145> ?p ?o ?g. }
- W2610028145 endingPage "436" @default.
- W2610028145 startingPage "436" @default.
- W2610028145 abstract "Pomegranate (Punica granatum L.), a nutrient-rich unique fruit, has been used for centuries for the prevention and treatment of various inflammation-driven diseases. Based on our previous study, a characterized pomegranate emulsion (PE) exhibited a striking inhibition of dimethylbenz(a)anthracene (DMBA)-initiated rat mammary tumorigenesis via antiproliferative and apoptosis-inducing mechanisms. The objective of the present work is to investigate the anti-inflammatory mechanism of action of PE during DMBA rat mammary carcinogenesis by evaluating the expression of cyclooxygenase-2 (COX-2), heat shock protein 90 (HSP90), nuclear factor-κB (NF-κB) and nuclear factor erythroid 2p45 (NF-E2)-related factor 2 (Nrf2). Mammary tumor samples were harvested from our previous chemopreventive study in which PE (0.2–5.0 g/kg) was found to reduce mammary tumorigenesis in a dose-dependent manner. The expressions of COX-2, HSP90, NF-κB, inhibitory κBα (IκBα) and Nrf2 were detected by immunohistochemical techniques. PE decreased the expression of COX-2 and HSP90, prevented the degradation of IκBα, hindered the translocation of NF-κB from cytosol to nucleus and increased the expression and nuclear translocation of Nrf2 during DMBA-induced mammary tumorigenesis. These findings, together with our previous results, indicate that PE-mediated prevention of DMBA-evoked mammary carcinogenesis may involve anti-inflammatory mechanisms through concurrent but differential regulation of two interrelated molecular pathways, namely NF-κB and Nrf2 signaling." @default.
- W2610028145 created "2017-05-05" @default.
- W2610028145 creator A5019852381 @default.
- W2610028145 creator A5041012906 @default.
- W2610028145 creator A5041230677 @default.
- W2610028145 date "2017-04-28" @default.
- W2610028145 modified "2023-09-26" @default.
- W2610028145 title "Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-κB and Nrf2 Signaling Pathways" @default.
- W2610028145 cites W1225960969 @default.
- W2610028145 cites W1504008270 @default.
- W2610028145 cites W1516746818 @default.
- W2610028145 cites W1523693806 @default.
- W2610028145 cites W183114306 @default.
- W2610028145 cites W1891389145 @default.
- W2610028145 cites W1966903210 @default.
- W2610028145 cites W1972487149 @default.
- W2610028145 cites W1973354681 @default.
- W2610028145 cites W1978470743 @default.
- W2610028145 cites W1979124011 @default.
- W2610028145 cites W1984609427 @default.
- W2610028145 cites W1985845719 @default.
- W2610028145 cites W1990143638 @default.
- W2610028145 cites W1994878958 @default.
- W2610028145 cites W2000944787 @default.
- W2610028145 cites W2001633855 @default.
- W2610028145 cites W2003193511 @default.
- W2610028145 cites W2003402207 @default.
- W2610028145 cites W2004325913 @default.
- W2610028145 cites W2021488853 @default.
- W2610028145 cites W2022300670 @default.
- W2610028145 cites W2023497885 @default.
- W2610028145 cites W2024893745 @default.
- W2610028145 cites W2028078823 @default.
- W2610028145 cites W2031028803 @default.
- W2610028145 cites W2031220614 @default.
- W2610028145 cites W2037691927 @default.
- W2610028145 cites W2039898654 @default.
- W2610028145 cites W2042159996 @default.
- W2610028145 cites W2052942682 @default.
- W2610028145 cites W2054760917 @default.
- W2610028145 cites W2056542792 @default.
- W2610028145 cites W2058118671 @default.
- W2610028145 cites W2058189541 @default.
- W2610028145 cites W2059649811 @default.
- W2610028145 cites W2060031759 @default.
- W2610028145 cites W2060902443 @default.
- W2610028145 cites W2063591253 @default.
- W2610028145 cites W2064175068 @default.
- W2610028145 cites W2066634650 @default.
- W2610028145 cites W2067132771 @default.
- W2610028145 cites W2068633850 @default.
- W2610028145 cites W2073704436 @default.
- W2610028145 cites W2074143255 @default.
- W2610028145 cites W2077966345 @default.
- W2610028145 cites W2078561648 @default.
- W2610028145 cites W2080635229 @default.
- W2610028145 cites W2082764531 @default.
- W2610028145 cites W2084311049 @default.
- W2610028145 cites W2087108175 @default.
- W2610028145 cites W2090449909 @default.
- W2610028145 cites W2090784980 @default.
- W2610028145 cites W2091772830 @default.
- W2610028145 cites W2092460415 @default.
- W2610028145 cites W2094863064 @default.
- W2610028145 cites W2095931589 @default.
- W2610028145 cites W2100590284 @default.
- W2610028145 cites W2101422131 @default.
- W2610028145 cites W2104477238 @default.
- W2610028145 cites W2107135234 @default.
- W2610028145 cites W2115639400 @default.
- W2610028145 cites W2118148875 @default.
- W2610028145 cites W2118150025 @default.
- W2610028145 cites W2118278569 @default.
- W2610028145 cites W2119944195 @default.
- W2610028145 cites W2123712628 @default.
- W2610028145 cites W2127975859 @default.
- W2610028145 cites W2136347443 @default.
- W2610028145 cites W2140446330 @default.
- W2610028145 cites W2141149861 @default.
- W2610028145 cites W2142013301 @default.
- W2610028145 cites W2146166890 @default.
- W2610028145 cites W2147554742 @default.
- W2610028145 cites W2149093383 @default.
- W2610028145 cites W2149494499 @default.
- W2610028145 cites W2152901181 @default.
- W2610028145 cites W2157707826 @default.
- W2610028145 cites W2157942810 @default.
- W2610028145 cites W2166450414 @default.
- W2610028145 cites W2168188385 @default.
- W2610028145 cites W2169648776 @default.
- W2610028145 cites W2193282869 @default.
- W2610028145 cites W2198388098 @default.
- W2610028145 cites W2235523093 @default.
- W2610028145 cites W2236070174 @default.
- W2610028145 cites W2292763601 @default.
- W2610028145 cites W2575521580 @default.
- W2610028145 doi "https://doi.org/10.3390/nu9050436" @default.
- W2610028145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5452166" @default.