Matches in SemOpenAlex for { <https://semopenalex.org/work/W2610252645> ?p ?o ?g. }
- W2610252645 endingPage "1620" @default.
- W2610252645 startingPage "1613" @default.
- W2610252645 abstract "Camellia japonica L. is a plant of which the seeds are used as a folk medicine, and it is native to South Korea, Japan and China. In previous study, triterpenes, flavonoids, tannins and fatty acids which have antiviral, antioxidant and anti inflammatory activity were reported from C. japonica leaf and flower. In Korea, the seed from this plant is used as a traditional medicine and in folk remedies for the treatment of bleeding and inflammation. However, the major issue associated with the use of the seed as a medicinal and/or functional food ingredient is its application to the pharmaceutical and food industry. First, the productivity of seed extract is very much less than that of the leaf. Second, the beneficial usage of the seed extract as an alternative medicine and functional source is not yet clear. Thus, in this study, we focused on another part of the plant, the leaf, and found that the extract of Camellia japonica leaf has a high concentration of vitamin E, rutin and other biologically active compounds related to hyperuricemia. We aimed to investigate the biological activities, namely the antioxidant activities, xanthine oxidase (XO) inhibitory activity and anti‑hyperuricemic effects of extract from C. japonica leaf and the phytochemicals contained therein. Ethanol extracts of C. japonica leaf (ECJL) were prepared, and the extract was used with respect to antioxidant activities, total phenolic contents and XO inhibitory activity. The in vivo XO inhibitory activity and anti‑hyperuricemic effects of the extract were evaluated in mice with potassium oxonate‑induced hyperuricemia. To clarify the marker compounds that are responsible for the anti‑hyperuricemic effects, several key constituents were identified using gas chromatography‑mass spectrometry (GC‑MS) and and liquid chromatography-mass spectrometry (LC-MS). ECJL was found to have strong antioxidant activities, and in vitro XO inhibitory activity. The results of the in vivo experiments using mice demonstrated that ECJL at the doses of 100 and 300 mg/kg inhibited hepatic XO activity and significantly attenuated hyperuricemia. To the best of our knowledge, the present study is the first report on the XO inhibitory and anti-hyperuricemic effects of ECJL, which can be therapeutically applied in the treatment of hyperuricemia and gout." @default.
- W2610252645 created "2017-05-12" @default.
- W2610252645 creator A5001158987 @default.
- W2610252645 creator A5011547643 @default.
- W2610252645 creator A5016091775 @default.
- W2610252645 creator A5019897388 @default.
- W2610252645 creator A5026000618 @default.
- W2610252645 creator A5034474133 @default.
- W2610252645 creator A5061644857 @default.
- W2610252645 creator A5062906473 @default.
- W2610252645 creator A5069581313 @default.
- W2610252645 creator A5071248130 @default.
- W2610252645 creator A5081120906 @default.
- W2610252645 creator A5089229710 @default.
- W2610252645 date "2017-05-03" @default.
- W2610252645 modified "2023-10-15" @default.
- W2610252645 title "Identification of the biologically active constituents of Camellia japonica leaf and anti-hyperuricemic effect in vitro and in vivo" @default.
- W2610252645 cites W1591385381 @default.
- W2610252645 cites W1746060998 @default.
- W2610252645 cites W1977694695 @default.
- W2610252645 cites W1982550547 @default.
- W2610252645 cites W1984341355 @default.
- W2610252645 cites W1991960405 @default.
- W2610252645 cites W1999978271 @default.
- W2610252645 cites W2005839352 @default.
- W2610252645 cites W2006533548 @default.
- W2610252645 cites W2010491625 @default.
- W2610252645 cites W2020392851 @default.
- W2610252645 cites W2028692318 @default.
- W2610252645 cites W2030401739 @default.
- W2610252645 cites W2039506610 @default.
- W2610252645 cites W2039744784 @default.
- W2610252645 cites W2046724696 @default.
- W2610252645 cites W2053861395 @default.
- W2610252645 cites W2068350058 @default.
- W2610252645 cites W2070292099 @default.
- W2610252645 cites W2088343376 @default.
- W2610252645 cites W2094063441 @default.
- W2610252645 cites W2112323509 @default.
- W2610252645 cites W2128387777 @default.
- W2610252645 cites W2150143220 @default.
- W2610252645 cites W2171230117 @default.
- W2610252645 cites W2238530391 @default.
- W2610252645 cites W2333677811 @default.
- W2610252645 cites W2334622123 @default.
- W2610252645 cites W2411936184 @default.
- W2610252645 cites W2806724185 @default.
- W2610252645 cites W4293247451 @default.
- W2610252645 cites W2023152379 @default.
- W2610252645 doi "https://doi.org/10.3892/ijmm.2017.2973" @default.
- W2610252645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28487949" @default.
- W2610252645 hasPublicationYear "2017" @default.
- W2610252645 type Work @default.
- W2610252645 sameAs 2610252645 @default.
- W2610252645 citedByCount "33" @default.
- W2610252645 countsByYear W26102526452017 @default.
- W2610252645 countsByYear W26102526452018 @default.
- W2610252645 countsByYear W26102526452019 @default.
- W2610252645 countsByYear W26102526452020 @default.
- W2610252645 countsByYear W26102526452021 @default.
- W2610252645 countsByYear W26102526452022 @default.
- W2610252645 countsByYear W26102526452023 @default.
- W2610252645 crossrefType "journal-article" @default.
- W2610252645 hasAuthorship W2610252645A5001158987 @default.
- W2610252645 hasAuthorship W2610252645A5011547643 @default.
- W2610252645 hasAuthorship W2610252645A5016091775 @default.
- W2610252645 hasAuthorship W2610252645A5019897388 @default.
- W2610252645 hasAuthorship W2610252645A5026000618 @default.
- W2610252645 hasAuthorship W2610252645A5034474133 @default.
- W2610252645 hasAuthorship W2610252645A5061644857 @default.
- W2610252645 hasAuthorship W2610252645A5062906473 @default.
- W2610252645 hasAuthorship W2610252645A5069581313 @default.
- W2610252645 hasAuthorship W2610252645A5071248130 @default.
- W2610252645 hasAuthorship W2610252645A5081120906 @default.
- W2610252645 hasAuthorship W2610252645A5089229710 @default.
- W2610252645 hasBestOaLocation W26102526451 @default.
- W2610252645 hasConcept C17857428 @default.
- W2610252645 hasConcept C185592680 @default.
- W2610252645 hasConcept C2778004101 @default.
- W2610252645 hasConcept C2779409272 @default.
- W2610252645 hasConcept C31903555 @default.
- W2610252645 hasConcept C55493867 @default.
- W2610252645 hasConcept C556039675 @default.
- W2610252645 hasConcept C59822182 @default.
- W2610252645 hasConcept C71924100 @default.
- W2610252645 hasConcept C86803240 @default.
- W2610252645 hasConceptScore W2610252645C17857428 @default.
- W2610252645 hasConceptScore W2610252645C185592680 @default.
- W2610252645 hasConceptScore W2610252645C2778004101 @default.
- W2610252645 hasConceptScore W2610252645C2779409272 @default.
- W2610252645 hasConceptScore W2610252645C31903555 @default.
- W2610252645 hasConceptScore W2610252645C55493867 @default.
- W2610252645 hasConceptScore W2610252645C556039675 @default.
- W2610252645 hasConceptScore W2610252645C59822182 @default.
- W2610252645 hasConceptScore W2610252645C71924100 @default.
- W2610252645 hasConceptScore W2610252645C86803240 @default.
- W2610252645 hasIssue "6" @default.
- W2610252645 hasLocation W26102526451 @default.