Matches in SemOpenAlex for { <https://semopenalex.org/work/W2610273044> ?p ?o ?g. }
- W2610273044 endingPage "2276" @default.
- W2610273044 startingPage "2262" @default.
- W2610273044 abstract "Pulmonary vascular disease is characterized by remodeling and loss of microvessels and is typically attributed to pathological responses in vascular endothelium or abnormal smooth muscle cell phenotypes. We have challenged this understanding by defining an adult pulmonary mesenchymal progenitor cell (MPC) that regulates both microvascular function and angiogenesis. The current understanding of adult MPCs and their roles in homeostasis versus disease has been limited by a lack of genetic markers with which to lineage label multipotent mesenchyme and trace the differentiation of these MPCs into vascular lineages. Here, we have shown that lineage-labeled lung MPCs expressing the ATP-binding cassette protein ABCG2 (ABCG2+) are pericyte progenitors that participate in microvascular homeostasis as well as adaptive angiogenesis. Activation of Wnt/β-catenin signaling, either autonomously or downstream of decreased BMP receptor signaling, enhanced ABCG2+ MPC proliferation but suppressed MPC differentiation into a functional pericyte lineage. Thus, enhanced Wnt/β-catenin signaling in ABCG2+ MPCs drives a phenotype of persistent microvascular dysfunction, abnormal angiogenesis, and subsequent exacerbation of bleomycin-induced fibrosis. ABCG2+ MPCs may, therefore, account in part for the aberrant microvessel function and remodeling that are associated with chronic lung diseases." @default.
- W2610273044 created "2017-05-12" @default.
- W2610273044 creator A5001488233 @default.
- W2610273044 creator A5006025604 @default.
- W2610273044 creator A5007044953 @default.
- W2610273044 creator A5009783988 @default.
- W2610273044 creator A5012119171 @default.
- W2610273044 creator A5019303741 @default.
- W2610273044 creator A5030467856 @default.
- W2610273044 creator A5042419219 @default.
- W2610273044 creator A5042548894 @default.
- W2610273044 creator A5053227531 @default.
- W2610273044 creator A5053271274 @default.
- W2610273044 creator A5056044508 @default.
- W2610273044 creator A5063872240 @default.
- W2610273044 creator A5065305905 @default.
- W2610273044 creator A5065762639 @default.
- W2610273044 creator A5080485212 @default.
- W2610273044 creator A5083894684 @default.
- W2610273044 creator A5090398738 @default.
- W2610273044 date "2017-05-02" @default.
- W2610273044 modified "2023-10-12" @default.
- W2610273044 title "Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction" @default.
- W2610273044 cites W1244702794 @default.
- W2610273044 cites W1634464802 @default.
- W2610273044 cites W1699053637 @default.
- W2610273044 cites W1852620511 @default.
- W2610273044 cites W1962154935 @default.
- W2610273044 cites W1964805361 @default.
- W2610273044 cites W1968524593 @default.
- W2610273044 cites W1969047155 @default.
- W2610273044 cites W1969170720 @default.
- W2610273044 cites W1970159560 @default.
- W2610273044 cites W1974171881 @default.
- W2610273044 cites W1976016129 @default.
- W2610273044 cites W1981750198 @default.
- W2610273044 cites W1985260356 @default.
- W2610273044 cites W1990464394 @default.
- W2610273044 cites W1992112921 @default.
- W2610273044 cites W1993228795 @default.
- W2610273044 cites W1994553956 @default.
- W2610273044 cites W1995046740 @default.
- W2610273044 cites W1996631625 @default.
- W2610273044 cites W1997157125 @default.
- W2610273044 cites W1999439792 @default.
- W2610273044 cites W1999713206 @default.
- W2610273044 cites W2000328242 @default.
- W2610273044 cites W2000711124 @default.
- W2610273044 cites W2002999999 @default.
- W2610273044 cites W2003425669 @default.
- W2610273044 cites W2005197933 @default.
- W2610273044 cites W2014553043 @default.
- W2610273044 cites W2014973010 @default.
- W2610273044 cites W2018421011 @default.
- W2610273044 cites W2020646157 @default.
- W2610273044 cites W2023848963 @default.
- W2610273044 cites W2025371271 @default.
- W2610273044 cites W2025860724 @default.
- W2610273044 cites W2026195614 @default.
- W2610273044 cites W2030019428 @default.
- W2610273044 cites W2030470655 @default.
- W2610273044 cites W2030673574 @default.
- W2610273044 cites W2031041123 @default.
- W2610273044 cites W2035005764 @default.
- W2610273044 cites W2037568417 @default.
- W2610273044 cites W2037896891 @default.
- W2610273044 cites W2039068212 @default.
- W2610273044 cites W2043826113 @default.
- W2610273044 cites W2045450215 @default.
- W2610273044 cites W2046170696 @default.
- W2610273044 cites W2047802007 @default.
- W2610273044 cites W2048240697 @default.
- W2610273044 cites W2050594817 @default.
- W2610273044 cites W2055916655 @default.
- W2610273044 cites W2060326723 @default.
- W2610273044 cites W2065599791 @default.
- W2610273044 cites W2066990977 @default.
- W2610273044 cites W2073290778 @default.
- W2610273044 cites W2073764409 @default.
- W2610273044 cites W2076491580 @default.
- W2610273044 cites W2080448840 @default.
- W2610273044 cites W2086929403 @default.
- W2610273044 cites W2089586958 @default.
- W2610273044 cites W2089664833 @default.
- W2610273044 cites W2090134402 @default.
- W2610273044 cites W2090863421 @default.
- W2610273044 cites W2092721126 @default.
- W2610273044 cites W2092882523 @default.
- W2610273044 cites W2092911875 @default.
- W2610273044 cites W2095443864 @default.
- W2610273044 cites W2097458810 @default.
- W2610273044 cites W2101276332 @default.
- W2610273044 cites W2103871834 @default.
- W2610273044 cites W2104010513 @default.
- W2610273044 cites W2104898886 @default.
- W2610273044 cites W2105325938 @default.
- W2610273044 cites W2107863445 @default.
- W2610273044 cites W2115390024 @default.