FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2610293396> ?p ?o ?g. }

• W2610293396 abstract "Abstract It is well documented that the tumor microenvironment profoundly impacts the etiology and progression of breast cancer, yet the contribution of the resident microbiome within breast tissue remains poorly understood. Tumor microenvironmental conditions, such as hypoxia and dense tumor stroma, predispose progressive phenotypes and therapy resistance, however the role of bacteria in this interplay remains uncharacterized. We hypothesized that the effect of individual bacterial secreted molecules on breast cancer viability and proliferation would be modulated by these tumor-relevant stressors differentially for cells at varying stages of progression. To test this, we incubated human breast adenocarcinoma cells (MDA-MB-231, MCF-DCIS.com ) and non-malignant breast epithelial cells (MCF-10A) with N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL), a quorum-sensing molecule from Pseudomonas aeruginosa that regulates bacterial stress responses. This molecule was selected because Pseudomonas was recently characterized as a significant fraction of the breast tissue microbiome and OdDHL is documented to impact mammalian cell viability. After OdDHL treatment, we demonstrated the greatest decrease in viability with the more malignant MDAMB-231 cells and an intermediate MCF-DCIS.com (ductal carcinoma in situ ) response. The responses were also culture condition (i.e. microenvironment) dependent. These results contrast the MCF-10A response, which demonstrated no change in viability in any culture condition. We further determined that the observed trends in breast cancer viability were due to modulation of proliferation for both cell types, as well as the induction of necrosis for MDA-MB-231 cells in all conditions. Our results provide evidence that bacterial quorum-sensing molecules interact with the host tissue environment to modulate breast cancer viability and proliferation, and that the effect of OdDHL is dependent on both cell type as well as microenvironment. Understanding the interactions between bacterial signaling molecules and the host tissue environment will allow for future studies that determine the contribution of bacteria to the onset, progression, and therapy response of breast cancer." @default.
• W2610293396 created "2017-05-12" @default.
• W2610293396 creator A5006378915 @default.
• W2610293396 creator A5008275970 @default.
• W2610293396 creator A5016579574 @default.
• W2610293396 creator A5023632589 @default.
• W2610293396 creator A5091288879 @default.
• W2610293396 date "2017-04-28" @default.
• W2610293396 modified "2023-10-17" @default.
• W2610293396 title "N-(3-oxododecanoyl)-L-homoserine lactone interactions in the breast tumor microenvironment: implications for breast cancer viability and proliferationin vitro" @default.
• W2610293396 cites W1505928288 @default.
• W2610293396 cites W1555009525 @default.
• W2610293396 cites W1965560515 @default.
• W2610293396 cites W1971995358 @default.
• W2610293396 cites W1973089587 @default.
• W2610293396 cites W1977554998 @default.
• W2610293396 cites W1990207898 @default.
• W2610293396 cites W1993614010 @default.
• W2610293396 cites W1995669962 @default.
• W2610293396 cites W1997001969 @default.
• W2610293396 cites W1998630067 @default.
• W2610293396 cites W2016488959 @default.
• W2610293396 cites W2029583475 @default.
• W2610293396 cites W2031368804 @default.
• W2610293396 cites W2033278321 @default.
• W2610293396 cites W2041255266 @default.
• W2610293396 cites W2045258297 @default.
• W2610293396 cites W2051692904 @default.
• W2610293396 cites W2059720379 @default.
• W2610293396 cites W2061546218 @default.
• W2610293396 cites W2069345401 @default.
• W2610293396 cites W2073924079 @default.
• W2610293396 cites W2077660666 @default.
• W2610293396 cites W2096404892 @default.
• W2610293396 cites W2110872766 @default.
• W2610293396 cites W2113061812 @default.
• W2610293396 cites W2120807407 @default.
• W2610293396 cites W2124496728 @default.
• W2610293396 cites W2137521271 @default.
• W2610293396 cites W2154043802 @default.
• W2610293396 cites W2158303916 @default.
• W2610293396 cites W2172231399 @default.
• W2610293396 cites W2235965240 @default.
• W2610293396 cites W2331628193 @default.
• W2610293396 cites W2403952484 @default.
• W2610293396 cites W2415924547 @default.
• W2610293396 cites W2461220095 @default.
• W2610293396 cites W2466831718 @default.
• W2610293396 cites W2488877191 @default.
• W2610293396 cites W2490676660 @default.
• W2610293396 cites W2493607481 @default.
• W2610293396 cites W2560365758 @default.
• W2610293396 doi "https://doi.org/10.1101/132092" @default.
• W2610293396 hasPublicationYear "2017" @default.
• W2610293396 type Work @default.
• W2610293396 sameAs 2610293396 @default.
• W2610293396 citedByCount "1" @default.
• W2610293396 countsByYear W26102933962023 @default.
• W2610293396 crossrefType "posted-content" @default.
• W2610293396 hasAuthorship W2610293396A5006378915 @default.
• W2610293396 hasAuthorship W2610293396A5008275970 @default.
• W2610293396 hasAuthorship W2610293396A5016579574 @default.
• W2610293396 hasAuthorship W2610293396A5023632589 @default.
• W2610293396 hasAuthorship W2610293396A5091288879 @default.
• W2610293396 hasBestOaLocation W26102933961 @default.
• W2610293396 hasConcept C121608353 @default.
• W2610293396 hasConcept C1491633281 @default.
• W2610293396 hasConcept C203014093 @default.
• W2610293396 hasConcept C204232928 @default.
• W2610293396 hasConcept C2776107976 @default.
• W2610293396 hasConcept C2779256057 @default.
• W2610293396 hasConcept C3020616263 @default.
• W2610293396 hasConcept C502942594 @default.
• W2610293396 hasConcept C52124034 @default.
• W2610293396 hasConcept C530470458 @default.
• W2610293396 hasConcept C53227056 @default.
• W2610293396 hasConcept C54355233 @default.
• W2610293396 hasConcept C55493867 @default.
• W2610293396 hasConcept C86803240 @default.
• W2610293396 hasConceptScore W2610293396C121608353 @default.
• W2610293396 hasConceptScore W2610293396C1491633281 @default.
• W2610293396 hasConceptScore W2610293396C203014093 @default.
• W2610293396 hasConceptScore W2610293396C204232928 @default.
• W2610293396 hasConceptScore W2610293396C2776107976 @default.
• W2610293396 hasConceptScore W2610293396C2779256057 @default.
• W2610293396 hasConceptScore W2610293396C3020616263 @default.
• W2610293396 hasConceptScore W2610293396C502942594 @default.
• W2610293396 hasConceptScore W2610293396C52124034 @default.
• W2610293396 hasConceptScore W2610293396C530470458 @default.
• W2610293396 hasConceptScore W2610293396C53227056 @default.
• W2610293396 hasConceptScore W2610293396C54355233 @default.
• W2610293396 hasConceptScore W2610293396C55493867 @default.
• W2610293396 hasConceptScore W2610293396C86803240 @default.
• W2610293396 hasLocation W26102933961 @default.
• W2610293396 hasLocation W26102933962 @default.
• W2610293396 hasOpenAccess W2610293396 @default.
• W2610293396 hasPrimaryLocation W26102933961 @default.
• W2610293396 hasRelatedWork W2108048884 @default.
• W2610293396 hasRelatedWork W2396720743 @default.
• W2610293396 hasRelatedWork W2524775780 @default.

• next