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- W2610323368 endingPage "1831" @default.
- W2610323368 startingPage "1811" @default.
- W2610323368 abstract "Nutrient availability controls the landscape of nutrient transporters present at the plasma membrane, notably by regulating their ubiquitylation and subsequent endocytosis. In yeast, this involves the Nedd4 ubiquitin ligase Rsp5 and arrestin-related trafficking adaptors (ARTs). ARTs are targeted by signaling pathways and warrant that cargo ubiquitylation and endocytosis appropriately respond to nutritional inputs. Here, we show that glucose deprivation regulates the ART protein Csr2/Art8 at multiple levels to trigger high-affinity glucose transporter endocytosis. Csr2 is transcriptionally induced in these conditions through the AMPK orthologue Snf1 and downstream transcriptional repressors. Upon synthesis, Csr2 becomes activated by ubiquitylation. In contrast, glucose replenishment induces CSR2 transcriptional shutdown and switches Csr2 to an inactive, deubiquitylated form. This glucose-induced deubiquitylation of Csr2 correlates with its phospho-dependent association with 14-3-3 proteins and involves protein kinase A. Thus, two glucose signaling pathways converge onto Csr2 to regulate hexose transporter endocytosis by glucose availability. These data illustrate novel mechanisms by which nutrients modulate ART activity and endocytosis." @default.
- W2610323368 created "2017-05-12" @default.
- W2610323368 creator A5034017331 @default.
- W2610323368 creator A5040469212 @default.
- W2610323368 creator A5048120756 @default.
- W2610323368 creator A5058570149 @default.
- W2610323368 creator A5059114290 @default.
- W2610323368 creator A5060414991 @default.
- W2610323368 creator A5070832697 @default.
- W2610323368 date "2017-05-03" @default.
- W2610323368 modified "2023-10-15" @default.
- W2610323368 title "Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis" @default.
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