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• W2610356039 abstract "Objective To compare the efficacy of two antidepressant treatment strategies in severely depressed in‐patients, that is, imipramine vs. venlafaxine, both with subsequent lithium addition in non‐responders. Method In‐patients ( n = 88) with major depressive disorder were randomized to 7‐week treatment with imipramine or venlafaxine (phase I). All non‐responders ( n = 44) received 4‐week plasma level‐targeted dose lithium addition (phase II ). Efficacy was evaluated after 11 weeks of treatment. Results Analyzing phases I and II combined, non‐inferiority was established and the difference in the proportion of responders ( HAM ‐D score reduction ≥50%) by the end of phase II demonstrated the venlafaxine‐lithium treatment strategy to be significantly superior to the imipramine‐lithium treatment strategy (77% vs. 52%) (χ 2 (1) = 6.03; P = 0.01). Regarding remission ( HAM ‐D score ≤ 7), 15 of 44 (34%) patients in the imipramine‐lithium treatment group were remitters compared to 22 of 44 (50%) patients in the venlafaxine‐lithium treatment group, a non‐significant difference. Patients in the venlafaxine‐lithium treatment group had a non‐significant larger mean HAM ‐D score reduction compared with patients in the imipramine‐lithium treatment group (16.1 vs. 13.5 points, respectively; Cohen's d = 0.30). Conclusion The venlafaxine‐lithium treatment strategy can be considered a valuable alternative for the imipramine‐lithium treatment strategy in the treatment of severely depressed in‐patients." @default.
• W2610356039 created "2017-05-12" @default.
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• W2610356039 date "2017-05-06" @default.
• W2610356039 modified "2023-09-23" @default.
• W2610356039 title "A randomized clinical trial comparing two two‐phase treatment strategies for in‐patients with severe depression" @default.
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• W2610356039 doi "https://doi.org/10.1111/acps.12743" @default.
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