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• W2610361582 abstract "Timothy Schacker, MD; Alexander J. Ryncarz, PhD; James Goddard; Kurt Diem;Mary Shaughnessy, RN; Lawrence Corey, MDContext.— Genitalulcerdiseasehasbeenepidemiologicallylinkedasariskfac-tor in the transmission of the human immunodeficiency virus 1 (HIV-1). While her-pes simplex virus 2 (HSV-2) is the most common cause of genital ulcers, no studyhas systematically evaluated the frequency or titer of HIV-1 virus in HSV-2 lesions.Objective.— To compare lesional HIV-1 RNA levels during and after genitalHSV-2 reactivation and to evaluate the frequency, titer, and duration of HIV-1 RNAshedding in lesions due to HSV-2.Design.— Convenience sample.Setting.— Sexually transmitted disease research clinic at the University ofWashington, Seattle.Patients.— Twelve HIV-infected men with a history of symptomatic HSV-2infection who underwent daily sampling of genital lesions for HIV-1 RNA by poly-merase chain reaction assay and HSV-2 by culture.Main Outcome Measure.— Detection of lesional HIV RNA and HSV-2.Results.— HIV-1 RNA was detected from lesional swabs in 25 of 26 consecu-tively studied HSV-2 episodes and on 67% of days in which genital lesions werenoted.TheHIV-1RNAtitersinlesionalswabsexceeded10000copies/mLofswabsamplein75%ofsamples(range,2.2-3.2310" @default.
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• W2610361582 date "2009-01-01" @default.
• W2610361582 modified "2023-09-24" @default.
• W2610361582 title "Simplex Virus Lesions in HIV-1-Infected Men Frequent Recovery of HIV-1 From Genital Herpes" @default.
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