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- W2610361695 endingPage "716" @default.
- W2610361695 startingPage "702" @default.
- W2610361695 abstract "Since its discovery in 1983, the protein clusterin (CLU) has been isolated from almost all human tissues and fluids and linked to the development of different physiopathological processes, including carcinogenesis and tumor progression. During the last few years, several studies have shown the cytoprotective role of secretory CLU in tumor cells, inhibiting their apoptosis and enhancing their resistance to conventional treatments including hormone depletion, chemotherapy, and radiotherapy. In an effort to determine the therapeutic potential that the inhibition of this protein could have on the development of new strategies for cancer treatment, numerous studies have been carried out in this field, with results, in most cases, satisfactory but sometimes contradictory. In this document, we summarize for the first time the current knowledge of the effects that CLU inhibition has on sensitizing tumor cells to conventional cancer treatments and discuss its importance in the development of new strategies against cancer." @default.
- W2610361695 created "2017-05-12" @default.
- W2610361695 creator A5013703565 @default.
- W2610361695 creator A5020163776 @default.
- W2610361695 creator A5049752008 @default.
- W2610361695 creator A5054868492 @default.
- W2610361695 date "2017-08-01" @default.
- W2610361695 modified "2023-09-26" @default.
- W2610361695 title "Clusterin inhibition mediates sensitivity to chemotherapy and radiotherapy in human cancer" @default.
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