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- W2610362686 abstract "T Lymphocyte recognition of antigens leads to the formation of a highly organized structure termed immune synapse ( IS ) by analogy with the neuronals synapse. Sorting nexin 27 ( SNX27 ) controls the endosomal traffic of PSD95, Dlg1, ZO‐1 ( PDZ ) domain‐interacting proteins, and its alteration is associated with impaired synaptic function and neurological diseases. In T‐lymphocytes, SNX27 ‐positive vesicles polarize to the IS , the identity of SNX27 interactors in these conditions nonetheless remains unknown. Here we used proteomics to analyze the SNX27 interactome purified from IS ‐forming T cells, and confirmed the conserved nature of the SNX27 / WASH /retromer association in hematopoietic cells. Furthermore, our comparative interactome analysis of SNX27 wild‐type and a mutant‐deficient for PDZ cargo recognition identified the epithelial cell‐cell junction protein zona occludens‐2 ( ZO ‐2) as an IS component. Biochemistry and microscopy approaches in T cells confirmed SNX27 / ZO ‐2 PDZ ‐dependent interaction, and demonstrated its role controlling the dynamic localization of ZO ‐2 at the IS . This study broadens our knowledge of SNX27 function in T lymphocytes, and suggests that pathways that delimit polarized structures in nervous and epithelial systems also participate in IS regulation." @default.
- W2610362686 created "2017-05-12" @default.
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- W2610362686 date "2017-06-29" @default.
- W2610362686 modified "2023-10-03" @default.
- W2610362686 title "Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse" @default.
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- W2610362686 doi "https://doi.org/10.1111/tra.12492" @default.
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