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• W2610366627 abstract "Although important for dosing and dilution, there are few data describing botulinum toxin (BT) movement in human muscle.To better understand BT movement within human muscle.Proof-of-concept study with descriptive case series.Outpatient academic practice.Five subjects with stroke who were BT naive with a mean age of 60.4 ± 14 years and time poststroke of 4.6 ± 3.7 years.Three standardized injections were given to the lateral gastrocnemius muscle (LGM): 2 contained 25 units (U) of onabotulinumtoxinA (Botox) in 0.25 mL of saline solution and the third 0.25 mL of saline solution only. The tibialis anterior muscle (TAM) was not injected in any subject. A leg magnetic resonance image was obtained at baseline, 2 months, and 3 months later with a 3.0 Tesla Siemens scanner. Three muscles, the LGM, lateral soleus muscle (LSM), and TAM, were manually outlined on the T2 mapping sequence at each time point. A histogram of T2 relaxation times (T2-RT) for all voxels at baseline was used to calculate a mean and standard deviation (SD) T2-RT for each muscle. Botulinum toxin muscle effect (BTME) at 2 months and 3 months was defined as a subject- and muscle-specific T2-RT voxel threshold ≥3 SD above the baseline mean at or near BT injection sites.BTME volume for each leg magnetic resonance imaging slice at 3 time points and 3 muscles for all subjects.One subject missed the 3-month scan, leaving 18 potential observations of BTME. Little to no BTME effect was seen in the noninjected TAM. A BTME was detected in the LGM in 13 of 18 possible observations, and no effect was detected in 5 observations. Possible BTME effect was seen in the LSM in 3 subjects due to either diffusion through fascia or needle misplacement. Volume of BTME, as defined here, appeared to be substantially greater than the 0.25-mL injection volume.This descriptive case series is among the first attempts to quantify BTME within human muscle. Our findings are preliminary and are limited by a few inconsistencies. However, we conclude that use of magnetic resonance imaging to detect the volume of BTME is feasible and may assist researchers in modeling the spread and diffusion of BT within human muscle.IV." @default.
• W2610366627 created "2017-05-12" @default.
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• W2610366627 date "2017-05-05" @default.
• W2610366627 modified "2023-10-17" @default.
• W2610366627 title "Detection of Botulinum Toxin Muscle Effect in Humans Using Magnetic Resonance Imaging: A Qualitative Case Series" @default.
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• W2610366627 cites W1967841521 @default.
• W2610366627 cites W1972838299 @default.
• W2610366627 cites W1979522058 @default.
• W2610366627 cites W1984383186 @default.
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• W2610366627 cites W1991165373 @default.
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• W2610366627 cites W2035314491 @default.
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• W2610366627 cites W2055951512 @default.
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• W2610366627 cites W2081792373 @default.
• W2610366627 cites W2083138315 @default.
• W2610366627 cites W2089967566 @default.
• W2610366627 cites W2092249142 @default.
• W2610366627 cites W2092735646 @default.
• W2610366627 cites W2093614306 @default.
• W2610366627 cites W2093696965 @default.
• W2610366627 cites W2095659113 @default.
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• W2610366627 cites W2106420234 @default.
• W2610366627 cites W2106779213 @default.
• W2610366627 cites W2107536519 @default.
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• W2610366627 cites W2136247797 @default.
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• W2610366627 cites W2318043205 @default.
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• W2610366627 doi "https://doi.org/10.1016/j.pmrj.2017.04.014" @default.
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