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- W2610366974 abstract "Abstract We report the discovery of three toxicologically relevant methylated phenylarsenical metabolites in the liver of chickens fed 3‐nitro‐4‐hydroxyphenylarsonic acid (ROX), a feed additive in poultry production that is still in use in several countries. Methyl‐3‐nitro‐4‐hydroxyphenylarsonic acid (methyl‐ROX), methyl‐3‐amino‐4‐hydroxyphenylarsonic acid (methyl‐3‐AHPAA), and methyl‐3‐acetamido‐4‐hydroxyphenylarsonic acid (or methyl‐ N ‐acetyl‐ROX, methyl‐ N ‐AHPAA) were identified in such chicken livers, and the concentration of methyl‐ROX was as high as 90 μg kg −1 , even after a five‐day clearance period. The formation of these newly discovered methylated metabolites from reactions involving trivalent phenylarsonous acid substrates, S‐adenosylmethionine, and the arsenic (+3 oxidation state) methyltransferase enzyme As3MT suggests that these compounds are formed by addition of a methyl group to a trivalent phenylarsenical substrate in an enzymatic process. The IC 50 values of the trivalent phenylarsenical compounds were 300–30 000 times lower than those of the pentavalent phenylarsenicals." @default.
- W2610366974 created "2017-05-12" @default.
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- W2610366974 date "2017-05-04" @default.
- W2610366974 modified "2023-10-01" @default.
- W2610366974 title "Methylated Phenylarsenical Metabolites Discovered in Chicken Liver" @default.
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- W2610366974 doi "https://doi.org/10.1002/anie.201700736" @default.
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