FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2610371799> ?p ?o ?g. }

• W2610371799 endingPage "228" @default.
• W2610371799 startingPage "221" @default.
• W2610371799 abstract "Oxidative stress has been implicated in the pathogenesis of neurodegenerative disorders, such as vascular cognitive impairment (VCI). The present study was performed to investigate the potential neuroprotective effect of the antioxidant astaxanthin (ATX) in a mouse model of VCI. VCI was induced in male ICR mice by repeated occlusion of the bilateral common carotid artery, leading to repeated cerebral ischemia/reperfusion (IR) injury. After surgery, the mice received ATX or an equal volume of vehicle by daily intragastric administration for 28 days. The results showed that ATX treatment ameliorated learning and memory deficits after repeated cerebral IR. ATX administration rescued the number of surviving pyramidal neurons in the CA1 and CA3 regions. The concentration of malondialdehyde was decreased, and the levels of reduced glutathione and superoxide dismutase in the hippocampus were increased. Electron microphotography revealed that damage to the ultrastructure of neurons was also reduced by ATX administration. In addition, the expression levels of Cytochrome C (Cyt C), cleaved Caspase-3 and Bax were lower and the expression of Bcl-2 was higher compared to control IR mice. Our findings demonstrate that ATX is able to suppresse learning and memory impairment caused by repeated cerebral IR and that this effect is associated with attenuation of oxidative stress." @default.
• W2610371799 created "2017-05-12" @default.
• W2610371799 creator A5007281157 @default.
• W2610371799 creator A5038814883 @default.
• W2610371799 creator A5044421638 @default.
• W2610371799 creator A5051678053 @default.
• W2610371799 creator A5066999889 @default.
• W2610371799 creator A5069560545 @default.
• W2610371799 creator A5077114895 @default.
• W2610371799 date "2017-05-01" @default.
• W2610371799 modified "2023-10-16" @default.
• W2610371799 title "The protective effect of astaxanthin on learning and memory deficits and oxidative stress in a mouse model of repeated cerebral ischemia/reperfusion" @default.
• W2610371799 cites W1528741819 @default.
• W2610371799 cites W1753629688 @default.
• W2610371799 cites W1900968643 @default.
• W2610371799 cites W1966257841 @default.
• W2610371799 cites W1975648951 @default.
• W2610371799 cites W1977281817 @default.
• W2610371799 cites W1996281559 @default.
• W2610371799 cites W2000926951 @default.
• W2610371799 cites W2015329090 @default.
• W2610371799 cites W2022439030 @default.
• W2610371799 cites W2031879414 @default.
• W2610371799 cites W2032267184 @default.
• W2610371799 cites W2036794114 @default.
• W2610371799 cites W2043494185 @default.
• W2610371799 cites W2045879332 @default.
• W2610371799 cites W2046879748 @default.
• W2610371799 cites W2049752408 @default.
• W2610371799 cites W2060956504 @default.
• W2610371799 cites W2067286327 @default.
• W2610371799 cites W2073703426 @default.
• W2610371799 cites W2074693398 @default.
• W2610371799 cites W2075720668 @default.
• W2610371799 cites W2075977497 @default.
• W2610371799 cites W2094887155 @default.
• W2610371799 cites W2119017540 @default.
• W2610371799 cites W2130445890 @default.
• W2610371799 cites W2144963147 @default.
• W2610371799 cites W2286008054 @default.
• W2610371799 cites W2291015124 @default.
• W2610371799 cites W2418495191 @default.
• W2610371799 cites W2514527057 @default.
• W2610371799 cites W2558098655 @default.
• W2610371799 cites W2581671813 @default.
• W2610371799 cites W399855955 @default.
• W2610371799 cites W960013482 @default.
• W2610371799 doi "https://doi.org/10.1016/j.brainresbull.2017.04.019" @default.
• W2610371799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28479214" @default.
• W2610371799 hasPublicationYear "2017" @default.
• W2610371799 type Work @default.
• W2610371799 sameAs 2610371799 @default.
• W2610371799 citedByCount "49" @default.
• W2610371799 countsByYear W26103717992018 @default.
• W2610371799 countsByYear W26103717992019 @default.
• W2610371799 countsByYear W26103717992020 @default.
• W2610371799 countsByYear W26103717992021 @default.
• W2610371799 countsByYear W26103717992022 @default.
• W2610371799 countsByYear W26103717992023 @default.
• W2610371799 crossrefType "journal-article" @default.
• W2610371799 hasAuthorship W2610371799A5007281157 @default.
• W2610371799 hasAuthorship W2610371799A5038814883 @default.
• W2610371799 hasAuthorship W2610371799A5044421638 @default.
• W2610371799 hasAuthorship W2610371799A5051678053 @default.
• W2610371799 hasAuthorship W2610371799A5066999889 @default.
• W2610371799 hasAuthorship W2610371799A5069560545 @default.
• W2610371799 hasAuthorship W2610371799A5077114895 @default.
• W2610371799 hasConcept C118552586 @default.
• W2610371799 hasConcept C126322002 @default.
• W2610371799 hasConcept C134018914 @default.
• W2610371799 hasConcept C169900460 @default.
• W2610371799 hasConcept C25498285 @default.
• W2610371799 hasConcept C2775838275 @default.
• W2610371799 hasConcept C2776151105 @default.
• W2610371799 hasConcept C2778401633 @default.
• W2610371799 hasConcept C2780114680 @default.
• W2610371799 hasConcept C2781161787 @default.
• W2610371799 hasConcept C3018842126 @default.
• W2610371799 hasConcept C42219234 @default.
• W2610371799 hasConcept C541997718 @default.
• W2610371799 hasConcept C71924100 @default.
• W2610371799 hasConcept C98274493 @default.
• W2610371799 hasConceptScore W2610371799C118552586 @default.
• W2610371799 hasConceptScore W2610371799C126322002 @default.
• W2610371799 hasConceptScore W2610371799C134018914 @default.
• W2610371799 hasConceptScore W2610371799C169900460 @default.
• W2610371799 hasConceptScore W2610371799C25498285 @default.
• W2610371799 hasConceptScore W2610371799C2775838275 @default.
• W2610371799 hasConceptScore W2610371799C2776151105 @default.
• W2610371799 hasConceptScore W2610371799C2778401633 @default.
• W2610371799 hasConceptScore W2610371799C2780114680 @default.
• W2610371799 hasConceptScore W2610371799C2781161787 @default.
• W2610371799 hasConceptScore W2610371799C3018842126 @default.
• W2610371799 hasConceptScore W2610371799C42219234 @default.
• W2610371799 hasConceptScore W2610371799C541997718 @default.
• W2610371799 hasConceptScore W2610371799C71924100 @default.
• W2610371799 hasConceptScore W2610371799C98274493 @default.
• W2610371799 hasLocation W26103717991 @default.

• next