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• W2610410189 abstract "Summary Based on the above mechanisms of mRNA degradation, an integrated model of mRNA turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be degraded by the deadenylation-dependent pathway at some rate. In addition to this default pathway, another layer of complexity would come from degradation mecha- nisms specific to individual mRNAs or to classes of mRNAs. Such mRNA-specific mechanisms would include sequence-specific endonuclease cleavage and deadeny- lation-independent decapping. Thus, the overall decay rate of an individual transcript will be a function of its sus- ceptibility to these turnover pathways. In addition, cis- acting sequences that specify mRNA decay rate, as well as regulatory inputs that control mRNA turnover, are likely to affect all the steps of these decay pathways. One important goal in future work will be to identify the gene products that are responsible for the nucleolytic events in these pathways and to delineate how specific mRNA features act to affect the function of these degrada- tive activities. The identification of distinct mRNA decay pathways should allow genetic and biochemical ap- proaches that can be designed to identify these gene prod- ucts. A second important goal is to understand the nature of the interaction between the 5' and 3' termini, which may also be critical for efficient translation." @default.
• W2610410189 created "2017-05-12" @default.
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• W2610410189 date "1995-01-01" @default.
• W2610410189 modified "2023-09-26" @default.
• W2610410189 title "Degradation of mRNA in Eukaryotes Review" @default.
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