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- W2610498449 abstract "Cerebrovascular reactivity (CVR) is the cerebral hemodynamic response to a vasoactive substance. Breath-hold (BH) induced CVR has the advantage of being non-invasive and easy to implement during magnetic resonance imaging (MRI). We systematically reviewed the literature regarding MRI measurement of BH induced CVR. The literature was searched using MEDLINE with the search terms breath-hold; and MRI or cerebrovascular reactivity. The search yielded 2244 results and 54 articles were included. Between-group comparisons have found that CVR was higher among healthy controls than patients with various pathologies (e.g. sleep apnea, diabetes, hypertension etc.). However, counter-intuitive findings have also been reported, including higher CVR among smokers, sedentary individuals, and patients with schizophrenia vs. controls. Methodological studies have highlighted important measurement characteristics (e.g. normalizing signal to end-tidal CO2), and comparisons of BH induced CVR to non-BH methods. Future studies are warranted to address questions about group differences, treatment response, disease progression, and other salient clinical themes. Standardization of CVR and BH designs is needed to fully exploit the potential of this practical non-invasive method." @default.
- W2610498449 created "2017-05-12" @default.
- W2610498449 creator A5007129670 @default.
- W2610498449 creator A5059053922 @default.
- W2610498449 creator A5059575133 @default.
- W2610498449 date "2017-08-01" @default.
- W2610498449 modified "2023-10-17" @default.
- W2610498449 title "Cerebrovascular reactivity measured by functional magnetic resonance imaging during breath-hold challenge: A systematic review" @default.
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- W2610498449 doi "https://doi.org/10.1016/j.neubiorev.2017.05.003" @default.
- W2610498449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28487157" @default.
- W2610498449 hasPublicationYear "2017" @default.