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• W2610509541 abstract "Summary Oxidative stress and haemolysis‐associated nitric oxide ( NO ) depletion plays a crucial role in the development of vasculopathy in sickle cell anaemia ( SS ). However it remains unknown whether oxidative stress and haemolysis levels influence vascular function in patients with sickle haemoglobin C disease ( SC ). Microvascular response to heat (using Laser Doppler flowmetry on finger), oxidative stress biomarkers, NO metabolites, endothelin‐1 and haematological parameters were compared between patients with SS and SC . Vascular function, oxidative and nitrosative markers were also measured in healthy ( AA ) children. SS and SC had increased plasma advanced oxidation protein products ( AOPP ), malondialdehyde, plasma antioxidant activities and NO end products, compared to AA . SC had lower catalase activity compared to AA and SS . Haemolytic rate, glutathione peroxidase and nitrotyrosine concentrations were significantly increased in children with SS compared to SC and AA . SS and SC had impaired microvascular reactivity compared to AA . In SS , the plateau phase of the response to local thermal heating was negatively associated with nitrotyrosine and AOPP . No association between vascular function parameters and oxidative stress markers was observed in SC . Mild haemolysis in SC , compared to SS , may limit oxidative and nitrosative stress and could explain the better preserved microvascular function in this group." @default.
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• W2610509541 date "2017-05-03" @default.
• W2610509541 modified "2023-10-07" @default.
• W2610509541 title "Association between oxidative stress and vascular reactivity in children with sickle cell anaemia and sickle haemoglobin C disease" @default.
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• W2610509541 doi "https://doi.org/10.1111/bjh.14693" @default.
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