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• W2610587768 abstract "Unlike autosomal dominant polycystic kidney disease (ADPKD), autosomal recessive polycystic kidney disease (ARPKD) is not generally known to be associated with vascular abnormalities. Only 4 cases of ARPKD patients with intracranial aneurysms have been reported previously. We present 2 ARPKD patients with extracranial vascular abnormalities: a young man with infrarenal aortic and iliac artery aneurysms complicated by dissection and a teenage girl with multiple splenic and gastric artery aneurysms and arterial vascular malformations. These cases raise the question of whether vascular integrity and development may be impaired in ARPKD, perhaps through molecular mechanisms overlapping with ADPKD. This possibility is supported by studies in mice that show ARPKD gene expression in the walls of large blood vessels." @default.
• W2610587768 created "2017-05-12" @default.
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• W2610587768 date "2017-05-02" @default.
• W2610587768 modified "2023-10-14" @default.
• W2610587768 title "Extracranial Aneurysms in 2 Patients with Autosomal Recessive Polycystic Kidney Disease" @default.
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• W2610587768 doi "https://doi.org/10.1159/000475492" @default.
• W2610587768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5465521" @default.
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• W2610587768 hasPublicationYear "2017" @default.
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