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• W2610591545 endingPage "1435" @default.
• W2610591545 startingPage "1419" @default.
• W2610591545 abstract "Impaired neurodevelopment in preterm infants is caused by prematurity itself; however, hypoxia/ischemia, inflammation, and hyperoxia contribute to the extent of impairment. Because preterm birth is accompanied by a dramatic decrease in 17β-estradiol (E2) and progesterone, preliminary clinical studies have been carried out to substitute these steroids in preterm infants; however, they failed to confirm significantly improved neurologic outcomes. We therefore hypothesized that the persistently high postnatal production of fetal zone steroids [mainly dehydroepiandrosterone (DHEA)] until term could interfere with E2-mediated protection. We investigated whether E2 could reduce hyperoxia-mediated apoptosis in three immature glial cell types and detected the involved receptors. Thereafter, we investigated protection by the fetal zone steroids DHEA, 16α-hydroxy-DHEA, and androstenediol. For DHEA, the involved receptors were evaluated. We examined aromatases, which convert fetal zone steroids into more estrogenic compounds. Finally, cotreatment was compared against single hormone treatment to investigate synergism. In all cell types, E2 and fetal zone steroids resulted in significant dose-dependent protection, whereas the mediating receptors differed. The neuroprotection by fetal zone steroids highly depended on the cell type-specific expression of aromatases, the receptor repertoire, and the potency of the fetal zone steroids toward these receptors. No synergism in fetal zone steroid and E2 cotreatment was detected in two of three cell types. Therefore, E2 supplementation may not be beneficial with respect to neuroprotection because fetal zone steroids circulate in persistently high concentrations until term in preterm infants. Hence, a refined experimental model for preterm infants is required to investigate potential treatments." @default.
• W2610591545 created "2017-05-12" @default.
• W2610591545 creator A5005312281 @default.
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• W2610591545 date "2017-03-03" @default.
• W2610591545 modified "2023-09-26" @default.
• W2610591545 title "Protective Effects of Fetal Zone Steroids Are Comparable to Estradiol in Hyperoxia–Induced Cell Death of Immature Glia" @default.
• W2610591545 cites W1158620818 @default.
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• W2610591545 cites W1584917605 @default.
• W2610591545 cites W1588826234 @default.
• W2610591545 cites W1668732801 @default.
• W2610591545 cites W1823703368 @default.
• W2610591545 cites W1899136755 @default.
• W2610591545 cites W1969689856 @default.
• W2610591545 cites W1982365696 @default.
• W2610591545 cites W1987198104 @default.
• W2610591545 cites W1990918868 @default.
• W2610591545 cites W2006311582 @default.
• W2610591545 cites W2006618367 @default.
• W2610591545 cites W2007435247 @default.
• W2610591545 cites W2009891177 @default.
• W2610591545 cites W2010764455 @default.
• W2610591545 cites W2010867750 @default.
• W2610591545 cites W2014555650 @default.
• W2610591545 cites W2015307784 @default.
• W2610591545 cites W2017985531 @default.
• W2610591545 cites W2020218903 @default.
• W2610591545 cites W2023177599 @default.
• W2610591545 cites W2024344832 @default.
• W2610591545 cites W2026181314 @default.
• W2610591545 cites W2027801675 @default.
• W2610591545 cites W2028802718 @default.
• W2610591545 cites W2030313584 @default.
• W2610591545 cites W2033002398 @default.
• W2610591545 cites W2034057116 @default.
• W2610591545 cites W2035579482 @default.
• W2610591545 cites W2035848332 @default.
• W2610591545 cites W2036681693 @default.
• W2610591545 cites W2039447961 @default.
• W2610591545 cites W2041074336 @default.
• W2610591545 cites W2043791595 @default.
• W2610591545 cites W2044201781 @default.
• W2610591545 cites W2046389285 @default.
• W2610591545 cites W2046460375 @default.
• W2610591545 cites W2056915271 @default.
• W2610591545 cites W2059195671 @default.
• W2610591545 cites W2060182030 @default.
• W2610591545 cites W2067270199 @default.
• W2610591545 cites W2070648285 @default.
• W2610591545 cites W2071685912 @default.
• W2610591545 cites W2072756743 @default.
• W2610591545 cites W2073414670 @default.
• W2610591545 cites W2073976254 @default.
• W2610591545 cites W2081129926 @default.
• W2610591545 cites W2081659868 @default.
• W2610591545 cites W2085010459 @default.
• W2610591545 cites W2086158683 @default.
• W2610591545 cites W2089826638 @default.
• W2610591545 cites W2092753280 @default.
• W2610591545 cites W2101741807 @default.
• W2610591545 cites W2102118606 @default.
• W2610591545 cites W2107625098 @default.
• W2610591545 cites W2112082184 @default.
• W2610591545 cites W2121071871 @default.
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• W2610591545 cites W2160723825 @default.
• W2610591545 cites W2171929082 @default.
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• W2610591545 doi "https://doi.org/10.1210/en.2016-1763" @default.
• W2610591545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28323976" @default.
• W2610591545 hasPublicationYear "2017" @default.
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