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- W2610662528 endingPage "369" @default.
- W2610662528 startingPage "359" @default.
- W2610662528 abstract "Sturge–Weber Syndrome (SWS) is a neurocutaneous disease with clinical manifestations including ocular (glaucoma), cutaneous (port‐wine birthmark), neurologic (seizures), and vascular problems. Molecular mechanisms of SWS pathogenesis are initiated by the somatic mutation in GNAQ . Therefore, no definite treatments exist for SWS and treatment options only mitigate the intensity of its clinical manifestations. Biological assay design for drug discovery against this syndrome demands comprehensive knowledge on mechanisms which are involved in its pathogenesis. By analysis of the interrelated molecular targets of SWS, some in vitro bioassay systems can be allotted for drug screening against its progression. Development of such platforms of bioassay can bring along the implementation of high‐throughput screening of natural or synthetic compounds in drug discovery programs. Regarding the fact that study of molecular targets and their integration in biological assay design can facilitate the process of effective drug discovery; some potential biological targets and their respective biological assay for SWS drug discovery are propounded in this review. For this purpose, some biological targets for SWS drug discovery such as acetylcholinesterase, alkaline phosphatase, GABAergic receptors, Hypoxia‐Inducible Factor (HIF)‐1α and 2α are suggested." @default.
- W2610662528 created "2017-05-12" @default.
- W2610662528 creator A5018641683 @default.
- W2610662528 creator A5045058244 @default.
- W2610662528 date "2017-10-11" @default.
- W2610662528 modified "2023-10-18" @default.
- W2610662528 title "Potential biological targets for bioassay development in drug discovery of Sturge-Weber syndrome" @default.
- W2610662528 cites W1485873252 @default.
- W2610662528 cites W1505592935 @default.
- W2610662528 cites W1567372668 @default.
- W2610662528 cites W1622178385 @default.
- W2610662528 cites W169049268 @default.
- W2610662528 cites W1721827275 @default.
- W2610662528 cites W1856328802 @default.
- W2610662528 cites W1899116896 @default.
- W2610662528 cites W1942524720 @default.
- W2610662528 cites W1965310901 @default.
- W2610662528 cites W1967767166 @default.
- W2610662528 cites W1970731633 @default.
- W2610662528 cites W1972016035 @default.
- W2610662528 cites W1972191006 @default.
- W2610662528 cites W1972719099 @default.
- W2610662528 cites W1975788169 @default.
- W2610662528 cites W1976016371 @default.
- W2610662528 cites W1976393020 @default.
- W2610662528 cites W1977298789 @default.
- W2610662528 cites W1978936651 @default.
- W2610662528 cites W1980488232 @default.
- W2610662528 cites W1988269145 @default.
- W2610662528 cites W1993114852 @default.
- W2610662528 cites W1995818522 @default.
- W2610662528 cites W2005444068 @default.
- W2610662528 cites W2008728858 @default.
- W2610662528 cites W2008730474 @default.
- W2610662528 cites W2009867707 @default.
- W2610662528 cites W2018269934 @default.
- W2610662528 cites W2019106819 @default.
- W2610662528 cites W2019161148 @default.
- W2610662528 cites W2020809515 @default.
- W2610662528 cites W2020869052 @default.
- W2610662528 cites W2023142848 @default.
- W2610662528 cites W2023732057 @default.
- W2610662528 cites W2024691792 @default.
- W2610662528 cites W2029530216 @default.
- W2610662528 cites W2029827726 @default.
- W2610662528 cites W2032008785 @default.
- W2610662528 cites W2035046825 @default.
- W2610662528 cites W2035065414 @default.
- W2610662528 cites W2035685337 @default.
- W2610662528 cites W2036717568 @default.
- W2610662528 cites W2038709562 @default.
- W2610662528 cites W2039867374 @default.
- W2610662528 cites W2039888539 @default.
- W2610662528 cites W2041620528 @default.
- W2610662528 cites W2043100529 @default.
- W2610662528 cites W2043542397 @default.
- W2610662528 cites W2046044320 @default.
- W2610662528 cites W2049860537 @default.
- W2610662528 cites W2053520756 @default.
- W2610662528 cites W2062158179 @default.
- W2610662528 cites W2063439014 @default.
- W2610662528 cites W2069032610 @default.
- W2610662528 cites W2073618740 @default.
- W2610662528 cites W2074929682 @default.
- W2610662528 cites W2076106665 @default.
- W2610662528 cites W2076621946 @default.
- W2610662528 cites W2077517114 @default.
- W2610662528 cites W2081648338 @default.
- W2610662528 cites W2082051046 @default.
- W2610662528 cites W2084411911 @default.
- W2610662528 cites W2085280593 @default.
- W2610662528 cites W2085907924 @default.
- W2610662528 cites W2086931499 @default.
- W2610662528 cites W2088242289 @default.
- W2610662528 cites W2090106876 @default.
- W2610662528 cites W2095960690 @default.
- W2610662528 cites W2107966379 @default.
- W2610662528 cites W2109855928 @default.
- W2610662528 cites W2112743255 @default.
- W2610662528 cites W2113603647 @default.
- W2610662528 cites W2114915384 @default.
- W2610662528 cites W2115818189 @default.
- W2610662528 cites W2117406743 @default.
- W2610662528 cites W2119211173 @default.
- W2610662528 cites W2121192401 @default.
- W2610662528 cites W2124814452 @default.
- W2610662528 cites W2127713680 @default.
- W2610662528 cites W2135130510 @default.
- W2610662528 cites W2135836641 @default.
- W2610662528 cites W2135871178 @default.
- W2610662528 cites W2143568978 @default.
- W2610662528 cites W2144093895 @default.
- W2610662528 cites W2144420455 @default.
- W2610662528 cites W2144461421 @default.
- W2610662528 cites W2148347015 @default.
- W2610662528 cites W2149507234 @default.
- W2610662528 cites W2153283433 @default.
- W2610662528 cites W2158569619 @default.