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- W2610685280 abstract "High-risk multiple myeloma (MM) patients may acquire new clonal abnormalities and present with aggressive rapidly growing relapses and sometimes secondary plasma cell leukemia (PCL). An aggressive approach to therapy including allogeneic-hematopoietic cell transplantation (allo-HCT) with the intent to produce a deep CR and prevent further relapse is warranted in these patients. Primary PCL is an aggressive neoplasm and patients generally present at a younger age and with worse performance status at diagnosis compared to MM patients. Treatment options for relapsed MM after allo-HCT include donor lymphocyte infusions (DLI) alone or in combination with salvage chemotherapy. Compared with auto-HCT recipients, allo-HCT recipients were more likely to be in complete remissions and also molecular CR (MCR). Current data support the concept that while an Minimal residual disease (MRD) negative state is associated with longer relapse-free survival and reduced relapse rates, the presence of MRD does not uniformly equate with impending relapse." @default.
- W2610685280 created "2017-05-12" @default.
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- W2610685280 date "2017-05-06" @default.
- W2610685280 modified "2023-10-12" @default.
- W2610685280 title "Allogeneic hematopoietic transplant in multiple myeloma" @default.
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- W2610685280 doi "https://doi.org/10.1002/9781119095491.ch23" @default.
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