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- W2610702564 abstract "Objectives: To compare the efficacy of intrapericardialcorticosteroid therapy to either oral corticosteroid therapyor intrapericardial placebo in addition to closed pericardiocentesisand anti-tuberculous therapy in patientswith tuberculous pericarditis. Methods: Patients with large pericardial effusions requiringpericardiocentesis were included. A short-courseanti-tuberculous regimen was initiated and patients wererandomised to one of three treatment groups: 200 mgintrapericardial triamcinolone hexacetonide; oral prednisoneplus intrapericardial placebo; or 5 ml intrapericardial0.9% saline (placebo). Patients were followed upfor at least one year. Results: Fifty-seven patients were included in the study;21 tested HIV positive (36.8%). Forty (70.0%) hadmicrobiological and / or histological evidence of tuberculosis,and 17 (30.0%) had a diagnosis based on clinicaland laboratory data. All patients responded well to initialpericardiocentesis. However, nine patients (16.0%) werelost to follow up. The hospitalisation duration for thesteroid groups was shorter than for the placebo group.This difference was not significant. Complications weresimilar for all arms. Conclusions: Intrapericardial and systemic corticosteroidswere well tolerated but did not improve the clinicaloutcome. The standard six-month regimen was effectiveregardless of HIV infection. The potential benefits fromadjunctive corticosteroids in the management of effusivetuberculous pericarditis could not be demonstrated inthis three-year study." @default.
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- W2610702564 date "2006-09-01" @default.
- W2610702564 modified "2023-09-23" @default.
- W2610702564 title "Experience with adjunctive corticosteroids in managing tuberculous pericarditis : cardiovascular topics" @default.
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