FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2610828536> ?p ?o ?g. }

• W2610828536 endingPage "582" @default.
• W2610828536 startingPage "572" @default.
• W2610828536 abstract "Understanding the mechanisms of immune resistance in pancreatic and ampullary cancers is crucial for the development of suitable biomarkers and effective immunotherapeutics. Our aim was to examine the expression of the immune inhibiting molecules PD-L1, Galectin-9, HVEM, IDO and HLA-G, as well as CD8+ and FoxP3+ tumor infiltrating lymphocytes (TIL), in pancreatic and ampullary cancers, and to relate their individual, as well as their combined expression, to cancer survival. Tumor tissue from 224 patients with resected pancreatic (n = 148) and ampullary (n = 76) cancer was used to construct tissue-microarrays. Expression of immune inhibitory molecules and TIL was examined by immunohistochemistry. We show that immune inhibitory molecules are prevalently expressed. Moreover, high tumor expression of PD-L1 (p = 0.002), Gal-9 (p = 0.003), HVEM (p = 0.001), IDO (p = 0.049), HLA-G (p = 0.004) and high CD8/FoxP3 TIL ratio (p = 0.006) were associated with improved cancer-specific survival. All immune biomarkers, with the exception of IDO, were individually predictive of cancer-specific survival when adjusted for clinicopathologic characteristics. For every additional immune biomarker present survival was almost two-fold prolonged (HR 0.57 95%CI 0.47-0.69, p < 0.0001). When patients with pancreatic and ampullary cancer were analyzed separately the results were similar. We conclude that pancreas and ampullary cancers are rich in expression of immune-inhibitory molecules. These molecules can be targets for future immunotherapeutics, as well as form powerful immunological biomarkers. We propose that such immune biomarker panels be included in future prospective immunotherapy trials." @default.
• W2610828536 created "2017-05-12" @default.
• W2610828536 creator A5010678703 @default.
• W2610828536 creator A5026070889 @default.
• W2610828536 creator A5031051209 @default.
• W2610828536 creator A5035951075 @default.
• W2610828536 creator A5042869763 @default.
• W2610828536 creator A5047837719 @default.
• W2610828536 creator A5051471434 @default.
• W2610828536 creator A5051516231 @default.
• W2610828536 creator A5053650454 @default.
• W2610828536 creator A5062633320 @default.
• W2610828536 creator A5069908102 @default.
• W2610828536 creator A5081704110 @default.
• W2610828536 date "2017-05-19" @default.
• W2610828536 modified "2023-09-27" @default.
• W2610828536 title "Tumor cell expression of immune inhibitory molecules and tumor-infiltrating lymphocyte count predict cancer-specific survival in pancreatic and ampullary cancer" @default.
• W2610828536 cites W1495262117 @default.
• W2610828536 cites W1630847696 @default.
• W2610828536 cites W1889335134 @default.
• W2610828536 cites W1915191412 @default.
• W2610828536 cites W1942897646 @default.
• W2610828536 cites W1965273547 @default.
• W2610828536 cites W1966648901 @default.
• W2610828536 cites W1976554463 @default.
• W2610828536 cites W1977692898 @default.
• W2610828536 cites W1982488143 @default.
• W2610828536 cites W1984484036 @default.
• W2610828536 cites W1988219173 @default.
• W2610828536 cites W2033672531 @default.
• W2610828536 cites W2036574174 @default.
• W2610828536 cites W2036810329 @default.
• W2610828536 cites W2036905020 @default.
• W2610828536 cites W2044835625 @default.
• W2610828536 cites W2049078823 @default.
• W2610828536 cites W2057893793 @default.
• W2610828536 cites W2063703161 @default.
• W2610828536 cites W2066230562 @default.
• W2610828536 cites W2070715664 @default.
• W2610828536 cites W2074932800 @default.
• W2610828536 cites W2095947137 @default.
• W2610828536 cites W2106787323 @default.
• W2610828536 cites W2110845266 @default.
• W2610828536 cites W2117156688 @default.
• W2610828536 cites W2118360431 @default.
• W2610828536 cites W2119064369 @default.
• W2610828536 cites W2124683381 @default.
• W2610828536 cites W2128640763 @default.
• W2610828536 cites W2132106534 @default.
• W2610828536 cites W2132543133 @default.
• W2610828536 cites W2135655382 @default.
• W2610828536 cites W2136731993 @default.
• W2610828536 cites W2136859769 @default.
• W2610828536 cites W2137015486 @default.
• W2610828536 cites W2151253787 @default.
• W2610828536 cites W2155464214 @default.
• W2610828536 cites W2160834915 @default.
• W2610828536 cites W2161367133 @default.
• W2610828536 cites W2161558877 @default.
• W2610828536 cites W2165480504 @default.
• W2610828536 cites W2194796823 @default.
• W2610828536 cites W2281321365 @default.
• W2610828536 cites W2327505660 @default.
• W2610828536 cites W2512560709 @default.
• W2610828536 cites W2566288566 @default.
• W2610828536 cites W4205811845 @default.
• W2610828536 cites W608522650 @default.
• W2610828536 doi "https://doi.org/10.1002/ijc.30760" @default.
• W2610828536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28470686" @default.
• W2610828536 hasPublicationYear "2017" @default.
• W2610828536 type Work @default.
• W2610828536 sameAs 2610828536 @default.
• W2610828536 citedByCount "52" @default.
• W2610828536 countsByYear W26108285362018 @default.
• W2610828536 countsByYear W26108285362019 @default.
• W2610828536 countsByYear W26108285362020 @default.
• W2610828536 countsByYear W26108285362021 @default.
• W2610828536 countsByYear W26108285362022 @default.
• W2610828536 countsByYear W26108285362023 @default.
• W2610828536 crossrefType "journal-article" @default.
• W2610828536 hasAuthorship W2610828536A5010678703 @default.
• W2610828536 hasAuthorship W2610828536A5026070889 @default.
• W2610828536 hasAuthorship W2610828536A5031051209 @default.
• W2610828536 hasAuthorship W2610828536A5035951075 @default.
• W2610828536 hasAuthorship W2610828536A5042869763 @default.
• W2610828536 hasAuthorship W2610828536A5047837719 @default.
• W2610828536 hasAuthorship W2610828536A5051471434 @default.
• W2610828536 hasAuthorship W2610828536A5051516231 @default.
• W2610828536 hasAuthorship W2610828536A5053650454 @default.
• W2610828536 hasAuthorship W2610828536A5062633320 @default.
• W2610828536 hasAuthorship W2610828536A5069908102 @default.
• W2610828536 hasAuthorship W2610828536A5081704110 @default.
• W2610828536 hasBestOaLocation W26108285361 @default.
• W2610828536 hasConcept C121608353 @default.
• W2610828536 hasConcept C126322002 @default.
• W2610828536 hasConcept C167672396 @default.
• W2610828536 hasConcept C193270364 @default.
• W2610828536 hasConcept C203014093 @default.

• next