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- W2610837327 endingPage "e0176826" @default.
- W2610837327 startingPage "e0176826" @default.
- W2610837327 abstract "Copper is an essential trace element, but can become toxic when present in abundance. The severe effects of copper-metabolism imbalance are illustrated by the inherited disorders Wilson disease and Menkes disease. The Labrador retriever dog breed is a novel non-rodent model for copper-storage disorders carrying mutations in genes known to be involved in copper transport. Besides disease initiation and progression of copper accumulation, the molecular mechanisms and pathways involved in progression towards copper-associated chronic hepatitis still remain unclear. Using expression levels of targeted candidate genes as well as transcriptome micro-arrays in liver tissue of Labrador retrievers in different stages of copper-associated hepatitis, pathways involved in progression of the disease were studied. At the initial phase of increased hepatic copper levels, transcriptomic alterations in livers mainly revealed enrichment for cell adhesion, developmental, inflammatory, and cytoskeleton pathways. Upregulation of targeted MT1A and COMMD1 mRNA shows the liver’s first response to rising intrahepatic copper concentrations. In livers with copper-associated hepatitis mainly an activation of inflammatory pathways is detected. Once the hepatitis is in the chronic stage, transcriptional differences are found in cell adhesion adaptations and cytoskeleton remodelling. In view of the high similarities in copper-associated hepatopathies between men and dog extrapolation of these dog data into human biomedicine seems feasible." @default.
- W2610837327 created "2017-05-12" @default.
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- W2610837327 date "2017-05-01" @default.
- W2610837327 modified "2023-10-18" @default.
- W2610837327 title "Gene expression patterns in the progression of canine copper-associated chronic hepatitis" @default.
- W2610837327 cites W1528606854 @default.
- W2610837327 cites W1674124552 @default.
- W2610837327 cites W1674731755 @default.
- W2610837327 cites W1754615655 @default.
- W2610837327 cites W1781311081 @default.
- W2610837327 cites W180631047 @default.
- W2610837327 cites W187968123 @default.
- W2610837327 cites W1971326367 @default.
- W2610837327 cites W1975762656 @default.
- W2610837327 cites W1975805673 @default.
- W2610837327 cites W1976341765 @default.
- W2610837327 cites W1979838917 @default.
- W2610837327 cites W1985980245 @default.
- W2610837327 cites W1987133102 @default.
- W2610837327 cites W1988961413 @default.
- W2610837327 cites W1997431077 @default.
- W2610837327 cites W1997805873 @default.
- W2610837327 cites W1999253766 @default.
- W2610837327 cites W2002554762 @default.
- W2610837327 cites W2002724039 @default.
- W2610837327 cites W2005145657 @default.
- W2610837327 cites W2007740137 @default.
- W2610837327 cites W2019364864 @default.
- W2610837327 cites W2020378415 @default.
- W2610837327 cites W2020541351 @default.
- W2610837327 cites W2021654785 @default.
- W2610837327 cites W2022682828 @default.
- W2610837327 cites W2026564074 @default.
- W2610837327 cites W2027423466 @default.
- W2610837327 cites W2029614399 @default.
- W2610837327 cites W2031748763 @default.
- W2610837327 cites W2037529563 @default.
- W2610837327 cites W2038955988 @default.
- W2610837327 cites W2039207263 @default.
- W2610837327 cites W2039517040 @default.
- W2610837327 cites W2040734911 @default.
- W2610837327 cites W2048612294 @default.
- W2610837327 cites W2051891646 @default.
- W2610837327 cites W2052987925 @default.
- W2610837327 cites W2058221230 @default.
- W2610837327 cites W2058954498 @default.
- W2610837327 cites W2059073584 @default.
- W2610837327 cites W2063827075 @default.
- W2610837327 cites W2065389632 @default.
- W2610837327 cites W2065446350 @default.
- W2610837327 cites W2067380652 @default.
- W2610837327 cites W2070087374 @default.
- W2610837327 cites W2072383565 @default.
- W2610837327 cites W2072550971 @default.
- W2610837327 cites W2076622939 @default.
- W2610837327 cites W2077951014 @default.
- W2610837327 cites W2079954571 @default.
- W2610837327 cites W2080040488 @default.
- W2610837327 cites W2082429191 @default.
- W2610837327 cites W2084565768 @default.
- W2610837327 cites W2087565169 @default.
- W2610837327 cites W2093477805 @default.
- W2610837327 cites W2096410114 @default.
- W2610837327 cites W2099495219 @default.
- W2610837327 cites W2099739975 @default.
- W2610837327 cites W2100668965 @default.
- W2610837327 cites W2103180882 @default.
- W2610837327 cites W2104277391 @default.
- W2610837327 cites W2104281953 @default.
- W2610837327 cites W2118646628 @default.
- W2610837327 cites W2119362028 @default.
- W2610837327 cites W2122373849 @default.
- W2610837327 cites W2125812338 @default.
- W2610837327 cites W2127281349 @default.
- W2610837327 cites W2128389187 @default.
- W2610837327 cites W2129876249 @default.
- W2610837327 cites W2130819579 @default.
- W2610837327 cites W2134224836 @default.
- W2610837327 cites W2136540393 @default.
- W2610837327 cites W2137234652 @default.
- W2610837327 cites W2138613474 @default.
- W2610837327 cites W2140285523 @default.
- W2610837327 cites W2145696267 @default.
- W2610837327 cites W2149282262 @default.
- W2610837327 cites W2149832725 @default.
- W2610837327 cites W2152548309 @default.
- W2610837327 cites W2157308941 @default.
- W2610837327 cites W2159289870 @default.