FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2610854086> ?p ?o ?g. }

• W2610854086 abstract "Surgical stress provokes protein catabolism and hyperglycaemia that is enhanced in patients with type 2 diabetes (T2DM), and increases perioperative morbidity. This study hypothesized that perioperative administration of high dose intravenous (IV) amino acids (AA) will augment protein balance in T2DM patients receiving tight plasma glucose control via continuous IV insulin compared to standard plasma glucose control via subcutaneous (SC) insulin sliding scale.Eighteen patients with well-controlled T2DM (HbA1C% < 7.1) undergoing colorectal surgery were assigned randomly to receive standard glucose control (6-10 mmol/l, SC insulin, n = 9) or tight glucose control (4-6 mmol/l, IV insulin, n = 9). Both groups received general anaesthesia and epidural analgesia. AA (1 ml/kg h Aminoven™ 10%, ∼2.4 g/kg d) were infused via a peripheral vein for two 3-h periods: at the beginning of surgery and in the post-operative care unit. Whole-body protein and glucose kinetics were assessed by stable isotope tracers, L-[1-13C]leucine and [6,6-2H2]glucose.Whole-body protein balance was positive after surgery in all patients. Since protein synthesis, breakdown and leucine oxidation were comparable in both groups, whole body protein balance was not different (p = 0.605). Tight glucose control suppressed endogenous glucose production (EGP, p < 0.001) and increased glucose clearance (p < 0.001) compared to standard glucose control during both study periods. No episode of hypoglycaemia occurred in either group.High-dose perioperative AA administration under optimal anti-catabolic care with epidural analgesia was effective in achieving a positive protein balance in T2DM patients undergoing surgery that was independent of glycaemic control strategy. Continuous IV insulin maintained normoglycaemia by inhibiting EGP and increasing glucose clearance. Improved glucose control, without a pronounced increase in protein balance with the intravenous insulin regimen, suggests perioperative protein metabolism may be less sensitive to insulin than is glucose." @default.
• W2610854086 created "2017-05-12" @default.
• W2610854086 creator A5001313198 @default.
• W2610854086 creator A5003094934 @default.
• W2610854086 creator A5011365305 @default.
• W2610854086 creator A5051148803 @default.
• W2610854086 creator A5056693356 @default.
• W2610854086 creator A5065858217 @default.
• W2610854086 creator A5068428574 @default.
• W2610854086 creator A5077877075 @default.
• W2610854086 creator A5078216551 @default.
• W2610854086 creator A5085096112 @default.
• W2610854086 date "2018-08-01" @default.
• W2610854086 modified "2023-09-27" @default.
• W2610854086 title "High dose amino acid administration achieves an anabolic response in type 2 diabetic patients that is independent of glycaemic control: A randomized clinical trial" @default.
• W2610854086 cites W1380689 @default.
• W2610854086 cites W1529983368 @default.
• W2610854086 cites W1535883517 @default.
• W2610854086 cites W1617145133 @default.
• W2610854086 cites W1932029755 @default.
• W2610854086 cites W1964456146 @default.
• W2610854086 cites W1968453958 @default.
• W2610854086 cites W1969616767 @default.
• W2610854086 cites W1970671951 @default.
• W2610854086 cites W1980717583 @default.
• W2610854086 cites W1984242781 @default.
• W2610854086 cites W1986603533 @default.
• W2610854086 cites W1993840109 @default.
• W2610854086 cites W1994724507 @default.
• W2610854086 cites W1994797738 @default.
• W2610854086 cites W1995780597 @default.
• W2610854086 cites W1999023355 @default.
• W2610854086 cites W2000603379 @default.
• W2610854086 cites W2005392873 @default.
• W2610854086 cites W2006325333 @default.
• W2610854086 cites W2007397474 @default.
• W2610854086 cites W2013385068 @default.
• W2610854086 cites W2018683948 @default.
• W2610854086 cites W2025939037 @default.
• W2610854086 cites W2029215789 @default.
• W2610854086 cites W2032228419 @default.
• W2610854086 cites W2034773227 @default.
• W2610854086 cites W2048670184 @default.
• W2610854086 cites W2048853162 @default.
• W2610854086 cites W2049988272 @default.
• W2610854086 cites W2062435683 @default.
• W2610854086 cites W2062646103 @default.
• W2610854086 cites W2075443305 @default.
• W2610854086 cites W2091290608 @default.
• W2610854086 cites W2095028721 @default.
• W2610854086 cites W2096408798 @default.
• W2610854086 cites W2097330753 @default.
• W2610854086 cites W2098508236 @default.
• W2610854086 cites W2126479503 @default.
• W2610854086 cites W2140598688 @default.
• W2610854086 cites W2156183726 @default.
• W2610854086 cites W2160978530 @default.
• W2610854086 cites W2162589006 @default.
• W2610854086 cites W2164818281 @default.
• W2610854086 cites W2168261002 @default.
• W2610854086 cites W2282585473 @default.
• W2610854086 cites W2320086683 @default.
• W2610854086 cites W2403125639 @default.
• W2610854086 cites W2414650502 @default.
• W2610854086 cites W3143437408 @default.
• W2610854086 cites W348067615 @default.
• W2610854086 doi "https://doi.org/10.1016/j.clnu.2017.04.016" @default.
• W2610854086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28527646" @default.
• W2610854086 hasPublicationYear "2018" @default.
• W2610854086 type Work @default.
• W2610854086 sameAs 2610854086 @default.
• W2610854086 citedByCount "2" @default.
• W2610854086 countsByYear W26108540862019 @default.
• W2610854086 countsByYear W26108540862022 @default.
• W2610854086 crossrefType "journal-article" @default.
• W2610854086 hasAuthorship W2610854086A5001313198 @default.
• W2610854086 hasAuthorship W2610854086A5003094934 @default.
• W2610854086 hasAuthorship W2610854086A5011365305 @default.
• W2610854086 hasAuthorship W2610854086A5051148803 @default.
• W2610854086 hasAuthorship W2610854086A5056693356 @default.
• W2610854086 hasAuthorship W2610854086A5065858217 @default.
• W2610854086 hasAuthorship W2610854086A5068428574 @default.
• W2610854086 hasAuthorship W2610854086A5077877075 @default.
• W2610854086 hasAuthorship W2610854086A5078216551 @default.
• W2610854086 hasAuthorship W2610854086A5085096112 @default.
• W2610854086 hasConcept C1008401 @default.
• W2610854086 hasConcept C126322002 @default.
• W2610854086 hasConcept C134018914 @default.
• W2610854086 hasConcept C168563851 @default.
• W2610854086 hasConcept C185592680 @default.
• W2610854086 hasConcept C197683979 @default.
• W2610854086 hasConcept C2777180221 @default.
• W2610854086 hasConcept C2779306644 @default.
• W2610854086 hasConcept C2779572773 @default.
• W2610854086 hasConcept C31174226 @default.
• W2610854086 hasConcept C42219234 @default.
• W2610854086 hasConcept C515207424 @default.
• W2610854086 hasConcept C55493867 @default.
• W2610854086 hasConcept C555293320 @default.
• W2610854086 hasConcept C62231903 @default.

• next